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EC number: 281-719-9 | CAS number: 84029-45-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD study with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 4-(4-methyl-3-nitrobenzoylamino)benzenesulphonate
- EC Number:
- 281-719-9
- EC Name:
- Sodium 4-(4-methyl-3-nitrobenzoylamino)benzenesulphonate
- Cas Number:
- 84029-45-8
- Molecular formula:
- C14H12N2O6S.Na
- IUPAC Name:
- sodium 4-(4-methyl-3-nitrobenzoylamino)benzenesulphonate
- Details on test material:
- purity: 89.9 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Hoe: WISKf(SPF71)
- Source: HOECHST AG, Kastengrund, SPF-breeding
- Age at study initiation: males: about 7 weeks; females: about 8 weeks
- Weight at study initiation: males: 189 - 198 g; females: 159 - 175 g
- Fasting period before study: 16 hours
- Housing: in macrolone-cages in completely air-conditiones rooms
- Diet: Rattendiat Altromin 1324, ad libitum
- Water: tap water from trinking bottles, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-3
- Humidity (%): 50+-20
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2% potatoe starch in deionized water
- Details on oral exposure:
- dosis: 2000 mg/kg bw
concentration: 20 % (w/v)
application volume: 10 ml/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: twice a day and weighing: once a week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,
Results and discussion
- Preliminary study:
- doses: 500, 1000 and 2000 mg/kg bw with one male and one female per dose.
no mortality, normal development of the body weights
the animals of the 1000 mg group showed squatting posture at the day of application,
the animals of the 2000 mg goup showed additionally decreased sponataneous activity.
One day post application all these eymptoms were reversible
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- other: Decreased sonateous activity and squatting posture at the day of application. Completely reversible on the next day
- Gross pathology:
- no macroscopic findings
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the test result the LD50 ist greater than 2000 mg/kg bw for acute oral toxicity
- Executive summary:
The substance was tested for acute oral toxicity according to OECD guideline 401. 5 male and 5 femal Wistar-rats were administered one single dose of 2000 mg/kg bw via gavage. No mortality occured, only one female showed a reduced development of the body weight. Symptoms such as squatting posture and decreased spontaneous activity were reversible at the the day after application.
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