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EC number: 223-664-5 | CAS number: 4009-98-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- (methoxymethyl)triphenylphosphonium chloride
- EC Number:
- 223-664-5
- EC Name:
- (methoxymethyl)triphenylphosphonium chloride
- Cas Number:
- 4009-98-7
- Molecular formula:
- C20H20OP.Cl
- IUPAC Name:
- (methoxymethyl)triphenylphosphanium chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult animals (approx. 8 weeks old)
- Weight at study initiation: males mean of 288 g, females mean of 165-183 g
- Fasting period before study: overnight (for a maximum of 20 h)
- Housing:3 animals per sex/cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C +/- 3°C
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 17.12.2002 To: 07.01.2003
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
-
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg b.w. - Doses:
- 2000 mg/kg (10mL/kg) b.w.
200 mg/kg (10mL/kg) b.w. - No. of animals per sex per dose:
- 3 females 2000 mg/kg b.w.
3 females 200 mg/kg b.w.
3 males 200 mg/kg b.w. - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations: at 0, 2 and 4 h after dosing and once daily thereafter
- Frequency of weighing: day 1, day 8 and day 15
- Necropsy of survivors performed: yes
- Other examinations performed: gross examination of organs were subjected to necropsy and descriptions of all internal macroscopic
abnormalities recorded
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 200 - ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals at 2000 mg/kg b.w. were found dead. The decedents were found dead within 2 hour post treatment. No further mortality occurred at 200 mg/kg b.w..
- Clinical signs:
- other: 2000 mg/kg b.w.: lethargy, flat and hunched posture, salivation, moribund, slow breathing, piloerection, 200 mg/kg b.w.: restless, hunched posture, chromodacryorrhoea, lethargy The surviving animals had recovered from the symptoms between days 2 and 3.
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- At 2000 mg/kg b.w. all animals died within 2 hours after dosing. At 200 mg/kg b.w. no mortality occurred and therefore the LD50 was considered to be in the range of 300 - 2000 mg/kg b.w..
- Executive summary:
At 2000 mg/kg b.w. all animals died within 2 hours after dosing. At 200 mg/kg b.w. no mortality occurred and therefore the LD50 was considered to be in the range of 300 - 2000 mg/kg b.w.. Also at 200 mg/kg b.w. clinical signs such as restlessness, hunched posture, chromodacryorrhoea and lethargy were noted.
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