Registration Dossier
Registration Dossier
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EC number: 241-475-6 | CAS number: 17462-58-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound: acutely harmful to fish.
Hydrolysis product sec-butanol: With high probability acutely not harmful to fish.
Hydrolysis product HCl: Acutely toxic to fish (pH dependent).
Key value for chemical safety assessment
Additional information
Hydrolysis product HCl: 96 -h LC50 = 4.92 mg/L (OECD, 2002).
Sec-butyl chloroformate hydrolyses rapidly to sec-butanol, HCl and CO2. However, since the pH remained within acceptable limits, the clearly higher toxicity compared to sec-butanol must be due to the reactivity of unhydrolysed sec-butyl chloroformate at the beginning of the test. The higher toxicity may be explained by reactions with nucleophiles (such as -NH2, -SH and –OH) on biological macromolecules.
Species | Results | Remarks | Reference |
Danio rerio | LC50 (96 h) = ca. 46.4 mg/L (nominal), static fish acute toxicity test (OECD TG 203) | reliability: 2, key study | BASF AG, 1999 |
Pimephales promelas | LC50 (96 h) = 3670 mg/L (measured); acute fish toxicity test (flow-through) | Hydrolysis product sec-butanol; reliability: 2, key study | OECD, 2002 |
Cyprinus carpio | LC50 (96 h) = 4.92 mg/L (acid equivalent to pH 4.3), semi-static, with analytical monitoring, OECD TG 203 | Hydrolysis product HCl; reliability: 2, key study | OECD, 2002 |
Oncorhynchus mykiss | LC50 (96 h) = 7.45 mg/L (acid equivalent to pH 4.12), fish acute toxicity test | Hydrolysis product HCl; reliability: 2, supp. study | OECD, 2002 |
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