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Diss Factsheets
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EC number: 237-358-4 | CAS number: 13762-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- from January 2010 to July 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study was generated according to generally valid and accepted testing guidelines and performed according to GLP. In accordance to the ECHA guidance document “Practical guide 6: How to report read-across and categories (March 2010)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on the read-across substance molybdenum trioxide (CAS 1313-27-5).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Version / remarks:
- (92/69/EEC)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Molybdenum trioxide
- EC Number:
- 215-204-7
- EC Name:
- Molybdenum trioxide
- Cas Number:
- 1313-27-5
- IUPAC Name:
- trioxomolybdenum
- Details on test material:
- - Name of test material (as cited in study report): molybenum trioxide
- Physical state: solid, white powder
- Analytical purity: 99.96 %
- Expiration date of the lot/batch: January 2013
- Stability under test conditions: stable
- Storage condition of test material: at room temperature, in closed container, dry
- Particle size: aerodynamic mass median diameter = 3.1 µm
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles-River rat (strain:CD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder: Charles River Laboratories, Sandhofer Weg 7, 97633 Sulzfeld, Germany
- Age at study initiation: males 49-50 days; females 63-64 days
- Weight at study initiation: males 224-262 g; females 201 - 221 g
- Housing: granulated textured wood cages
- Commercial diet, ssniff® R/M-H V1534 served as food (ssniff Spezialdiäten GmbH, 59494 Soest, Germany
- Water: ad libitum
- Acclimation period: 5 adaption days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature of 20.5°C 0.2°C (main study); 20.8°C 0.2°C (sattelite group)
- humidity (55.7% ± 0.8% (main study) or 52.9% ± 0.5 (satellite group)
- The rooms were lit (150 lux at approx. 1.50 m room height) and darkened for periods of 12 hours each
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: dynamic inhalation apparatus, nose-only exposure chamber
- Exposure chamber volume: 40 L
- Method of holding animals in test chamber: animals in pyrex tubes at the edge of the chamber in radial position
- Source and rate of air: compressed air from surrounding atmosphere of laboratory room; inflow = 900 L/h
- At the bottom of the exposure chamber, the air was sucked off at a lower flow rate than it was created by the dust generator in order to produce a homogenous distribution and a positive pressure in the exposure chamber (inflow 900 L/h, outflow 800 L/h).
- System of generating particulates/aerosols: rotating brush dust generator
- Method of particle size determination: cascade impactor
TEST ATMOSPHERE
- Brief description of analytical method used: gravimetric analysis with an air sample filter and pump
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
- MMAD (Mass median aerodynamic diameter): 3.085 µm ((main study) or 3.100 µm (satellite animals).
- geometric standard deviation = 2.75 (main study) or 2.78 (satellite animals)
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Dust concentration was measured gravimetrically with an air sample filter and pump controlled by a rotameter. The particle size distribution was analysed using a cascade impactor accoring to May (1975).
- Duration of exposure:
- 4 h
- Concentrations:
- 5.05±0.13 mg MoO3/m³ (main study, 14-day sacrifice) and 5.00±0.13 mg MoO3/m³ (satellite group, 24-hour sacrifice)
- No. of animals per sex per dose:
- Three male and three female rats (main study, 14-day sacrifice)
In addition, three male and three female satellite animals for histopathological examination 24 hours post exposure were tested as a satellite group. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
In addition, three male and three female satellite animals for histopathological examination 24 hours post exposure were tested as a sattelite group.
During and following exposure, observations were made and recorded systematically; individual records were maintained for each animal. Careful clinical examinations were made at least twice daily until all symptoms subsided, thereafter each working day. Observations on mortality were made at least once daily (in the morning starting on test day 2) to minimize loss of animals to the study, e.g. necropsy or refrigeration of those animals found dead and isolation or sacrifice of weak or moribund animals.
Cageside observations included, but were not limited to: changes in the skin and fur, eyes, mucous membranes, respiratory, circulatory, autonomic and central nervous system, as well as somatomotor activity and behaviour pattern.
Particular attention was directed to observation of tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma. The animals were also observed for possible indications of respiratory irritation such as dyspnoea, rhinitis etc., as specified in more detail in section 4.7.2 of this report.
Individual weights of animals were determined once during the acclimatisation period, before and after the exposure on test day 1, on test days 3, 8 and 15. Changes in weight were calculated and recorded when survival exceeded one day. At the end of the test, all animals were weighed and sacrificed. - Statistics:
- no calculation as no mortality occurred
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.05 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- no deaths
- Clinical signs:
- other: A 4-hour inhalation exposure to molybdenum trioxide at a concentration of 5.05 mg/L air revealed slight dyspnoea (reduced frequency of respiration with increased volume) on test day 1 immediately after end of exposure until 3 hours post exposure in all 3
- Body weight:
- All animals gained the expected weight throughout the study period.
- Gross pathology:
- No pathological changes were detected at necropsy.
- Other findings:
- A 4-hour inhalation exposure to molybdenum trioxide at a concentration of 5.05 mg/L air (main study, 14-day sacrifice) or 5.00 mg/mL air (satellite group, 24h-sacrifice) did not reveal any test material-related histopathological changes in the nose (5 levels of the nasal turbinates), larynx, trachea and lungs (5 levels).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Molybdenum trioxide does not require classification either for acute inhalation toxicity or for respiratory irritation.
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