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Diss Factsheets
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EC number: 235-185-9 | CAS number: 12125-01-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
A proprietary guideline ASRIT study is available for fluoride toxicity; a number of supporting studies are reported in the EU RAR.
On the other hand ammonium toxicity to activated sludge was estimated in an ISO guideline study.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 510 mg/L
Additional information
As ammonium fluoride decomposes in an aqueous environment into ammonium and fluoride ions, toxicity of these two ions has been studied and the most conservative one has been kept for assessment.
Ammonium toxicity was evaluated in an activated sludge short term respiratory inhibition was tested on ammonium chloride according to ISO 8192 guideline.
The activated sludge inoculum used in this study originated from laboratory wastewater treatment plants fed with municipal sewage.
In the test conditions, after 30 min exposure, the EC50 obtained was graphically estimated at 1300 mg/L. At the highest concentration tested, 2000mg/L, inhibition rate is 67%.
The guideline-compliant Bayer study on Sodium Fluoride reports a 3-hour NOEC of 510 mg/L for activated sludge. The EU RAR summarises and reviews the other available data on the toxicity of fluoride to aquatic microorganisms; NOEC values of between 7.1 - 226 mg/L are reported.
In conclusion, considering the respective toxicity to activated sludge, the most conservative NOEC for fluoride from the ASRIT study is retained as key data for hazard assessment.
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