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EC number: 272-574-2 | CAS number: 68890-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
Link to relevant study record(s)
Description of key information
In this study Octopirox® was found to be highly photolytically unstable. The direct photolysis rate constant kd and half life t½ of the test item under laboratory conditions were determined to be 1.24 1/h (kd), 34 min (t½) for pH 9 and 3.09 (kd), 13 min (t½) for pH 4.
The correlation factor of the regression graphs of irradiated samples was ≥ 0.97, therefore pseudo first order kinetic model could be assumed.
The known transformation product NDO was formed under both test conditions. The estimated formation rate constants were significantly lower than the direct photolysis reaction rate constants of Octopirox® and therefore the formation of NDO could not be assumed as the solitary first step of the transformation pathway.
No unknown transformation products above 10 % of the initial active ingredient peak area were detected. At pH 4 no transformation products with UV detectable chromophores were observed after 125 h of irradiation. At pH 9 two groups of transformation products with differing UV absorption spectra were observed. The first group of transformation product with UV spectra comparable to the UV absorption spectrum of Octopirox® (maximum at approx. 303 nm) was vanished after 97 h of irradiation. The second group signals, with absorption maxima below 236 nm, showed increasing intensity up to 97 h of irradiation.
As a consequence of these observations it could be assumed that, resulting from the total termination of signals with an UV absorption maximum near 303 nm, the pyridinone ring system (chromophore) of the Octopirox® molecule was disintegrated by sunlight in up to 125 h of solar irradiation at 3060 µmol photons / s m2 (290-800 nm).
Key value for chemical safety assessment
- Half-life in water:
- 34 min
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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