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EC number: 915-589-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 21, 1986 - May 16, 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA (US EPA)
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA (US EPA)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Diisopropylbiphenyl and triisopropylbiphenyl
- EC Number:
- 915-589-8
- Molecular formula:
- not applicable for UVCB substance
- IUPAC Name:
- Diisopropylbiphenyl and triisopropylbiphenyl
- Details on test material:
- - Name of test material (as cited in study report): Diisopropyl biphenyl, isomeric mixture (acronym used: DIPB or di-IPB/tri-IPB)
- Substance type: organic
- Density: 0.9669 g/ml
- Physical state: clear liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Isomers composition: no data
- Lot/batch No.: NBP-3184823
- Expiration date of the lot/batch: no data
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CDR (Sprague-Dawley derived)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Species: Albino rats, CDR (Srague-Dawley derived)
- Source: Charles River Breeding Laboratories, Inc; Wilmington , Massachusetts, USA
- Age at study initiation: Young adults /approx. 9-12 weeks
- Weight at study initiation (prefasted): - Males: 250 - 338 g
- Females: 212 - 269 g
- Fasting period before study: approx. 18 h
- Housing: Group housed (6 per cage) during acclimation, individually during study in suspended stainless steel cages with wire mesh bottoms
- Diet: Purina Laboratory Chow, ad libitum
- Water: ad libitum
- Acclimation period: 8, 10 or 21 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5 - 24.5°C (= 67 - 76°F)
- Humidity (%): 30 - 70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Test material was administered by oral intubation, using a ball-tipped intubation needle fitted onto a syringe
- Doses:
- 4000 mg/kg, 5000 mg/kg, 6250 mg/kg
- No. of animals per sex per dose:
- 5 (except 5000 mg/kg dose: 10 male, 5 female)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1 h, 2 h, and 4 h after application; thereafter daily for 14 days
- Frequency of weighing: Pre-fast, post-fast, day 7 and day 14
- Necropsy of survivors performed: yes
- Gross postmortem examinations were performed on all animals which died or were found dead during the study
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- see table below
- Clinical signs:
- other: No abnormalities were observed during 4 h after application. 24 h after application and/or day 2 most animals exhibited hypoactivity, soft stool, fecal and/or urinary staining. All surviving animals were free of significant abnormalities at termination of
- Gross pathology:
- Postmortem examinations of animals found dead during the study revealed primarily changes in lungs and gastrointestinal tract.
Several animals exhibited changes in the stomach and intestine which were suggestive of a corrosive effect.
Other changes appeared to represent autolytic changes or antemortem stress.
Any other information on results incl. tables
Dose levels and mortality (excerpt from original report):
Dose level (mg/kg) |
Mortality |
|||
Male |
Female |
Total |
Time of death (day) |
|
4000 |
1/5 |
1/5 |
2/10 |
2 - 3 |
5000 (A) |
(4/5) a |
1/5 |
a |
2 – 7 |
5000 (B) |
2/5 |
- |
2/5 |
2 – 4 |
6250 |
2/5 |
1/5 |
3/10 |
2 - 3 |
a: Because the weight of males dosed initially at 5000 mg/kg [designated 5000 (A)] exceeded the weight range of males dosed at the other two levels, an additional group of males in the same weight range as males in the other two dose levels was dosed [(designated 5000 (B)].
Only data from the 5000 (B) group were considered for estimation of LD50.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The test substance, alkylation and transalkylation products of biphenyl with propene, showed low toxicity only.
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