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Diss Factsheets
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EC number: 205-201-9 | CAS number: 135-57-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Remarks:
- Results of abiotic assessment from surface water degradation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 60 day degradation (performed 2016-17)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- In-life work followed OECD 309 with radiolabelling at neutral pH, 12 C
Analysis performed to determine potential abiotic degradation products. - Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 309
- Version / remarks:
- In-life followed OECD 309
- Principles of method if other than guideline:
- An aerobic mineralisation study was performed by Fera Science Ltd. An analytical study was also subsequently performed by Fera Science Ltd. in order to identify the transformation products formed during the mineralisation study.
The structural identities for some of the transformation products have been suggested and a transformation pathway has been proposed.
A kinetics analysis was performed by Enviresearch - GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- 2-Aminothiophenyl-ring-14C(U)]-DBD
Source: Hartmann Analytic
Batch number: 670-025-1201-A-20160914-JHO
Appearance: Liquid
Molecular formula: C26H20N2O2S2
Specific Activity: 120.1 mCi / mmol
Radiochemical Purity 97.1 % (taken from CofA)
Received: 29/09/2016 - Radiolabelling:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Samples taken over period from Day 0 - Day 60
- Buffers:
- None - used natual lake water pH 7.3
- Details on test conditions:
- Non-sterile lake water, 12 C pH 7.3
- Duration:
- 60 d
- pH:
- 7.3
- Temp.:
- 12 °C
- Initial conc. measured:
- ca. 24 µg/L
- Remarks:
- Conditions set up for water biodegradation study OECD 309
- Number of replicates:
- 2
- Positive controls:
- yes
- Remarks:
- For biological assessment - sodium benzoate
- Statistical methods:
- Concentrations over varous time points (including Day 0 and Day 1) were plotted using KinGUII v2.1 to demonstrate the DT50/90.
- Preliminary study:
- An ‘initial mineralisation’ assessment was performed using duplicate samples.
Due to the rapid degradation a ‘repeat degradation’ assessment was performed specifically to track the degradation rate. - Test performance:
- On the day after dispensing, samples were treated with the substance at either concentrations of 1 μg/L or 24 μg/L.
The experimental samples were incubated in the dark at 12±2 °C. Immediately following application and at 5 hours and 1, 2, 5, 8, 15, 20, 29, 42, 50 and 60 days for the repeat degradation assessment, samples treated at 24 μg/L were removed from incubation and analysed for radioactivity.
Sub-samples from all treated waters were quantified by LSC. Samples treated at the higher concentration of 24 μg/L were analysed by HPLC-βRAM for transformation products. - Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Details on hydrolysis and appearance of transformation product(s):
- N-((1E)-4-oxo-2-sulfanylcyclohexa-2,5-dien-1-ylidene) benzamide, thought to be formed from cleavage of the disulfide bond with subsequent hydroxylation and oxidation
N-(2-((2-aminophenyl)disulfanyl)phenyl) benzamide, thought to be formed from biotic or abiotic cleavage of one amide function and release of benzoic acid
Details are provided in a summary report attached. - % Recovery:
- ca. 42
- pH:
- 7.3
- Temp.:
- 12 °C
- Duration:
- 1 d
- % Recovery:
- ca. 5
- pH:
- 7.3
- Temp.:
- 12 °C
- Duration:
- ca. 10 d
- % Recovery:
- ca. 2
- pH:
- 7.3
- Temp.:
- 12 °C
- Duration:
- ca. 60 d
- Key result
- pH:
- 7.3
- Temp.:
- 12 °C
- DT50:
- ca. 1 d
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- Although there was a rapid loss of the parent compound, residues were being detected at the end of the sampling period. This is though to be in part due to adsorption / desoroption processes slowly releasing the substance from surfaces, including sediments present in the natural lake water.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Although the data are derived from a freshwater biodegradation study using natural water, the abiotic processes demonstrate rapid hydrolysis under natural conditions, with the formation of hydrolytically stable transformation products.
- Executive summary:
An aerobic mineralisation study has been performed by Fera Science Ltd. An analytical study was also subsequently performed by Fera Science Ltd. in order to identify the transformation products formed during the mineralisation study.
The structural identities for some of the transformation products have been suggested and a transformation pathway has been proposed, together with a kinetics analysis performed by Enviresearch.
Results have shown that the parent substance does not fulfil the surface water criterion for persistent (P) or for very persistent (vP) substances. Of the many transformation products that were formed during the aerobic mineralisation study, some could potentially fulfil the surface water criterion for P or for vP under the conditions of the laboratory work.
It is recognised that while some transformation products may be P and/or vP, a qualitative assessment of the transformation products indicates that they are unlikely to fulfil the criterion for bioaccumulation B and so would not be considered to be PBT and/or vPvB substances.
Reference
Description of key information
Water solubility 0.048 mg/l and screening study not technically possible.
QSAR attempted and inconclusive
Biodegradation testing (60 days radiolabelled and cold studies) resulted in conclusion that DT50 for substance is < 1 day (neutral pH), but transformation products are more stable. Results of this work provide information relating to hydrolysis and identity of transformation products.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 d
- at the temperature of:
- 12 °C
Additional information
Standard screening study not technically possible due to low water solublity.
Modelling attempted, but relevance of data is questionable.
Abiotic degradation in surface water biodegradation testing provides reliable information n half-life.
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