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EC number: 231-511-9 | CAS number: 7601-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 April - 04 May 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium perchlorate
- EC Number:
- 231-511-9
- EC Name:
- Sodium perchlorate
- Cas Number:
- 7601-89-0
- Molecular formula:
- ClHO4.Na
- IUPAC Name:
- sodium perchlorate
- Reference substance name:
- Anydrous Sodium Perchlorate
- IUPAC Name:
- Anydrous Sodium Perchlorate
- Details on test material:
- - Name of test material (as cited in study report): Anydrous Sodium Perchlorate
- Substance type: Technical material
- Physical state: white powder
- Analytical purity: 98.21%
- Purity test date: 10/01/2008
- Lot/batch No.: GRL 0005/08
- Expiration date of the lot/batch: February 2010
- Storage condition of test material: Room temperature, keep hermetically closed. Store away from heat & ignition sources
- Other: Disposal - dilute with water
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Grimaud Freres Selection S.A.S., La Corbiere, Roussay, France
- Age at study initiation: 2 - 4 months
- Weight at study initiation: 3.0 ± 0.2 kg
- Housing: Individually in Pajon cages (50 x 57 x 75 cm)
- Diet: ad libitum 110C pelleted diet (SAFE, Augy, France).
- Water: ad libitum filtered by a FG Millipore membrane (0.22 micron)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3
- Humidity (%): 30 - 70%
- Air changes (per hr): approx. 12 cycles/hour of filtered, non-recycled air.
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 08 April 2008 To: 04 May 2008
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 100 mg of the test item in its original form
- Duration of treatment / exposure:
- One application to one eye and there was no rinsing after administration. The other eye acted as control.
- Observation period (in vivo):
- up to 12 days
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
The test material was not removed after exposure
SCORING SYSTEM:
Conjunctival lesions and discharge
Chemosis (lids and/or nictitating membranes)
. no swelling ...............................................................................................................................0
. any swelling above normal (includes nictitating membranes) ...................................... ..1
. obvious swelling with partial eversion of lids......................................................................2
. swelling with lids about half-closed......................................................................................3
. swelling with lids more than half-closed .............................................................................4
Redness (refers to palpebral and bulbar conjunctivae, cornea and iris)
. blood vessels normal ...............................................................................................................0
. a number of blood vessels definitely hyperemic (injected).................................................1
. diffuse, crimson colour, individual vessels not easily discernible ....................................2
. diffuse, beefy red........................................................................................................................3
Discharge
. absence of discharge .............................................................................................................. .0
. slight discharge (does not include small amounts normally found in
inner canthus) ..............................................................................................................................1
. discharge with moistening of lids and hairs adjacent to lids...............................................2
. discharge with moistening of lids and hairs on wide area around the eye........................3
Iris lesions
. normal ..........................................................................................................................................0
. markedly deepened rugae, congestion, swelling, moderate circum-corneal
hyperemia, or injection, any of these or combination of any thereof, iris still
reacting to light (sluggish reaction is positive) .......................................................................1
. no reaction to light, haemorrhage, gross destruction (any or all of these) ......................2
Corneal lesions
Degree of opacity (area most dense taken for reading)
. no ulceration or opacity..............................................................................................................0
. scattered or diffuse areas of opacity (other than slight dulling or normal lustre),
details of iris clearly visible ..........................................................................................................1
. easily discernible translucent area, details of iris slightly obscured ...................................2
. nacreous areas, no details of iris visible, size of pupil barely discernible ..........................3
. opaque cornea, iris not discernible through the opacity.......................................................4
Area of opacity
. one quarter (or less) but not zero..............................................................................................1
. greater than one quarter but less than a half...........................................................................2
. greater than one half but less than three quarters..................................................................3
. greater than three quarters up to whole area. .........................................................................4
Any other lesions observed were noted.
TOOL USED TO ASSESS SCORE: UV lamp/ 0.5% sodium fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72h
- Score:
- 2.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7-12 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7-12 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- mean
- Remarks:
- 2 rabbits
- Time point:
- other: 24-48-72h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72h
- Score:
- 0.67
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity intensity
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72h
- Score:
- 1.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours/ 6 days
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity area
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- other: 24-48-72h
- Score:
- 1.6
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours / 6 days
- Irritant / corrosive response data:
- Slight to marked chemosis was observed in all animals from day 1 until day 6, 9 or 11.
Slight to severe redness of the conjunctiva was noted in all animals from day 1 until day 6 (one animal) or 11 (two animals).
A clear to whitish purulent discharge was noted in all animals from day 1 until day 3 (two animals) or 4 (one animal).
An iritis was noted in 2/3 animals from day 1 until day 3 or 5 and on day 2 in 1/3 animals.
A slight or moderate corneal opacity was recorded in 2/3 animals on days 2 and 3. In the third animal, a slight to severe corneal opacity, which covered sometimes the whole area of the cornea, was noted from day 1 until day 5.
Brownish area on the third eyelid was observed in 1/3 animals from day 7 until day 11.
Mean scores calculated for each animal over 24, 48 and 72 hours were 2.0, 2.3 and 3.0 for chemosis, 2.3, 2.0 and 2.7 for redness of the conjunctiva, 0.7, 0.3 and 1.0 for iris lesions and 1.0, 1.0 and 2.3 for corneal opacity.
Any other information on results incl. tables
Table 1a: Individual ocular examinations and mean values of the scores recorded for each animal (24, 48 and 72 hours)
Rabbit Number |
Region of Eye |
Description of ocular reactions |
Scores |
Mean irritation score (1) |
Interpretation (+) (-) |
|||
1 hour Day 1 |
24 hours Day 2 |
48 hours Day 3 |
72 hours Day 4 |
|||||
62 |
Conjunctivae |
Chemosis |
2 |
2 |
2 |
2 |
2.0 |
(+) |
Redness |
3 |
3 |
2 |
2 |
2.3 |
(-) |
||
|
||||||||
Discharge |
1 |
2 |
1 |
0 |
1.0 |
|
||
|
||||||||
Iris |
|
1 |
1 |
1 |
0 |
0.7 |
(-) |
|
|
||||||||
Corneal opacity |
Intensity |
0 |
2 |
1 |
0 |
1.0 |
(-) |
|
Area |
0 |
1 |
1 |
0 |
0.7 |
|
||
|
||||||||
Other |
|
* |
* |
* |
* |
|
|
|
Fluorescein |
|
/ |
U |
U |
U |
|
|
|
|
||||||||
73 |
Conjunctivae |
Chemosis |
2 |
3 |
2 |
2 |
2.3 |
(+) |
Redness |
2 |
2 |
2 |
2 |
2.0 |
(-) |
||
|
||||||||
Discharge |
2 |
2 |
1 |
0 |
1.0 |
|
||
|
||||||||
Iris |
|
0 |
1 |
0 |
0 |
0.3 |
(-) |
|
|
||||||||
Corneal opacity |
Intensity |
0 |
2 |
1 |
0 |
1.0 |
(-) |
|
Area |
0 |
1 |
1 |
0 |
0.7 |
|
||
|
||||||||
Other |
|
* |
* |
* |
* |
|
|
|
Fluorescein |
|
/ |
U |
U |
U |
|
|
|
|
||||||||
816 |
Conjunctivae |
Chemosis |
2 |
3 |
3 |
3 |
3.0 |
(+) |
Redness |
2 |
2 |
3 |
3 |
2.7 |
(+) |
||
|
||||||||
Discharge |
2 |
S |
S |
S |
(2) |
|
||
|
||||||||
Iris |
|
1 |
1 |
1 |
1 |
1.0 |
(+) |
|
|
||||||||
Corneal opacity |
Intensity |
2 |
2 |
3 |
2 |
2.3 |
(+) |
|
Area |
2 |
4 |
4 |
2 |
3.3 |
|
||
|
||||||||
Other |
|
Su |
* |
* |
* |
|
|
|
Fluorescein |
|
/ |
U |
U |
U |
|
|
|
|
(1): mean of scores on days 2, 3 and 4 (2): not calculable
(+): irritant according to EEC criteria U: fluorescein (batch No. L653 & P756)
(-): non-irritant according to EEC criteria /: fluorescein not used
S: whitish purulent discharge Su: residual test item
*: none
Table 1b: Individual ocular examinations of the scores recorded for each animal (from Day 5 to Day 12)
Rabbit Number |
Region of Eye |
Description of ocular reactions |
Scores |
|||||||
Day 5 |
Day 6 |
Day7 |
Day 8 |
Day 9 |
Day 10 |
Day 11 |
Day 12 |
|||
62 |
Conjunctivae |
Chemosis |
1 |
1 |
0 |
- |
- |
- |
- |
- |
Redness |
1 |
1 |
0 |
- |
- |
- |
- |
- |
||
|
||||||||||
Discharge |
0 |
0 |
0 |
- |
- |
- |
- |
- |
||
|
||||||||||
Iris |
|
0 |
0 |
0 |
- |
- |
- |
- |
- |
|
|
||||||||||
Corneal opacity |
Intensity |
0 |
0 |
0 |
- |
- |
- |
- |
- |
|
Area |
0 |
0 |
0 |
- |
- |
- |
- |
- |
||
|
||||||||||
Other |
|
* |
* |
* |
- |
- |
- |
- |
- |
|
Fluorescein |
|
/ |
/ |
/ |
- |
- |
- |
- |
- |
|
|
||||||||||
73 |
Conjunctivae |
Chemosis |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
0 |
Redness |
2 |
2 |
2 |
2 |
1 |
1 |
1 |
0 |
||
|
||||||||||
Discharge |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
|
||||||||||
Iris |
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
||||||||||
Corneal opacity |
Intensity |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Area |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
|
||||||||||
Other |
|
* |
* |
* |
* |
* |
* |
* |
* |
|
Fluorescein |
|
/ |
/ |
/ |
/ |
/ |
/ |
/ |
/ |
|
|
||||||||||
816 |
Conjunctivae |
Chemosis |
2 |
1 |
1 |
1 |
1 |
0 |
0 |
0 |
Redness |
2 |
2 |
1 |
1 |
1 |
1 |
1 |
0 |
||
|
||||||||||
Discharge |
0 |
0 |
0 |
0 |
S |
S |
0 |
0 |
||
|
||||||||||
Iris |
|
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
||||||||||
Corneal opacity |
Intensity |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Area |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
|
||||||||||
Other |
|
* |
* |
ZB |
ZB |
ZB |
ZB |
ZB |
* |
|
Fluorescein |
|
U |
U |
/ |
/ |
/ |
/ |
/ |
/ |
|
|
*: none ZB: brownish area on the third eyelid
U: fluorescein (batch No. P756) -: ocular examination not performed
/: fluorescein not used
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 2
- Remarks:
- Criteria used for interpretation of results: other: Regulation (EC) No 1272/2008
- Conclusions:
- Under the experimental conditions of the study, the test item ANHYDROUS SODIUM PERCHLORATE (batch No. lot moyen du 10/01/08 test) was
irritant when administered by the ocular route to rabbits. - Executive summary:
- The potential of the test item ANHYDROUS SODIUM PERCHLORATE (batch No. lot moyen du 10/01/08 test) to induce ocular irritation was evaluated in rabbits according to OECD (No. 405, 24th April 2002) and EC (2004/73/EC, B.5, 29th April 2004) guidelines. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. Under the experimental conditions of the study, the test item ANHYDROUS SODIUM PERCHLORATE (batch No. lot moyen du 10/01/08 test) was irritant when administered by ocular route to rabbits and should be classified as Irritant, Category 2 under CLP (GHS).
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