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Diss Factsheets
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EC number: 273-195-5 | CAS number: 68953-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- occlusive application
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Institut für Toxikologie, Henkel KGaA, Düsseldorf, Germany
Test material
- Reference substance name:
- Fatty acids, C16-18 and C18-unsatd.
- EC Number:
- 266-932-7
- EC Name:
- Fatty acids, C16-18 and C18-unsatd.
- Cas Number:
- 67701-08-0
- IUPAC Name:
- 67701-08-0
- Details on test material:
- - Name of test material (as cited in study report): Edenor Ti Dest (FS010)
- Physical state: white, solid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Kleinrussen
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Thomae, Biberach, Germany
- Age at study initiation: adult
- Weight at study initiation: mean 2445 g
- Housing: individually in rabbit cages (Fa. Heinkel, Kuchen, Germany)
- Diet (e.g. ad libitum): Zucht-/Haltungsdiät 20 ZH 5 (Fa. Nohrlin GmbH, Bad Salzuflen, Germany)
- Water (e.g. ad libitum): drinking water; ad libitum
- Acclimation period: minumum 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 20 - 21
- Humidity (%): ca. 45 - 50
- Photoperiod (hrs dark / hrs light): 1 2 / 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 4 h
- Observation period:
- 15 days
- Number of animals:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: back of animals
- Site preparation: shaved 24 hours prior to application
- Type of wrap if used: 2.5x2.5cm cotton linen patch covered by a cling film and secured by adhesive tape and plastic band
SCORING SYSTEM:
Erythema:
0 - no erythema
1 - very slight erythema (barely perceptible)
2 - well-defined erythema
3 - moderate to severe erythema
4 - severe erythema (beet redness) to slight eschar formation (injuries in deep)
Edema:
0 - no edema
1- very slight edema (barely perceptible)
2 - slight edema (edges of area well defined by definite rising)
3 - moderate edema (raised appr. 1 mm)
4 - severe edema (raised >1 mm and extending beyond area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 4 animals
- Time point:
- other: mean 24 - 48 - 72 h
- Score:
- 1.8
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 4 animals
- Time point:
- other: mean 24 - 48 - 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
Any other information on results incl. tables
Readings:
Time | Animal | Erythema | Edema | Additional findings |
1 h | 1 | 1 | 2 | |
2 | 1 | 2 | ||
3 | 1 | 1 | ||
4 | 2 | 1 | ||
24 h | 1 | 3 | 1 | |
2 | 2 | 1 | ||
3 | 2 | 1 | ||
4 | 3 | 1 | ||
48 h | 1 | 2 | 1 | |
2 | 1 | 1 | ||
3 | 1 | 1 | ||
4 | 2 | 1 | ||
72 h | 1 | 2 | 1 | |
2 | 1 | 1 | ||
3 | 1 | 1 | ||
4 | 2 | 1 | ||
7 days | 1 | 0 | 0 | s |
2 | 0 | 0 | s | |
3 | 0 | 0 | ||
4 | 1 | 0 | s | |
10 days | 1 | 0 | 0 | |
2 | 0 | 0 | ||
3 | 0 | 0 | ||
4 | 0 | 0 | s | |
15 days | 1 | 0 | 0 | |
2 | 0 | 0 | ||
3 | 0 | 0 | ||
4 | 0 | 0 | ||
mean 24 - 48 - 72 h | 1 | 2.3 | 1.0 | |
2 | 1.3 | 1.0 | ||
3 | 1.3 | 1.0 | ||
4 | 2.3 | 1.0 | ||
mean | 1.8 | 1.0 |
s: scaling
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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