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Diss Factsheets
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EC number: 215-475-1 | CAS number: 1327-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro data
There are no data available for aluminatesilicate.
In the S. typhimurium test using five mutant strains (TA 97a, TA 98, TA100, TA 102 and TA1535), the related substance silicic acid, aluminium salt was found to be not mutagenic with or without metabolic activation (Paulus, 2010, RL2).
The related substance Silicic acid, aluminium sodium salt did not show mutagenic activity in a mammalian chromosome aberration test in human embryonic lung cells (Wi-38) without metabolic activation (Litton Bionetics, 1974, RL2). Amorphous Silica is also negative in HGPRT assay in Chinese hamster ovary cells with and without metabolic activation (Harbell et al., 1990, RL2). Silica, amorphous, fumed and cryst.-free was also negative in a DNA repair system, an UDS test, in primary rat hepatocytes (Curren, 1989, UDS, RL2).
In vivo data
There are no in vivo data for aluminatesilicate. However, there are data available for structural analogue substances. Synthetic amorphous silica did not lead to an increase in chromosomal aberrations in bone-marrow cells from orally treated rats (Litton Bionetics, 1974, RL2). Also dominant lethal assays conducted in rats did not produce significant adverse effects on reproductive performance parameters after exposure of male rats to synthetic amorphous silica (Litton Bionetics, 1974, RL2).
Following a repeated dose inhalation exposure (13 weeks) of rats to a mean dust concentration of 50 mg/m³ Aerosil 200, alveolar type-II cells were isolated from the broncho-alveolar lavage fluid (BAL) and subjected to the HPRT gene-mutation assayin vitro. There was no increase in 6TG-resistant mutants compared to controls (Johnston et al., 2000, RL2).
Short description of key information:
Based on the negative results of the related substance silicic acid, aluminium salt in the S. typhimurium Ames test and all tested synthetic amorphous silica (structural analogues) in the additional mammalian in vitro and in vivo studies, no mutagenic potential is expected from exposure to aluminatesilicate.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No need for classification as the Ames test with the related substance silicic acid, aluminium salt and all in vitro and in vivo studies consistently demonstrate negative results for all tested structurally related compounds.
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