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Diss Factsheets
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EC number: 601-672-3 | CAS number: 120118-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Non-human data:
Data on acute toxicity of chloro-cyano-p-tolyl-imidazole were available and several LD50 values for acute toxicity after oral application were reported:
In one oral acute toxicity study with Sprague-Dawley rats LD50 values of 324 and 443 mg/kg bw/day were reported for males and females, respectively.
In another oral acute toxicity studies with rats LD50 values between 300 and 500 mg/kg bw/day were reported. For this study the data submitter is data owner and the study was reported in more detail (see endpoint study record).
General clinical symptoms for acute toxicity in rodents are prone position, hunchback position, decrease in spontaneous motor activity, crawling, deep respiration, sedation, tremor, ptosis, salivation and soiled fur in the nasorostral region. These sign began to appear from 1 hour after administration and disappeared by day 1. At necropsy for the dead animals the gross findings were red-colored lung, red spots and edema in the lung, black spots in the glandular stomach, red-colored small intestine, edema in the small intestine, and soiled fur in the nasorostral regions. No macroscoplic abnormalities were noted in surviving animals at necropsy (day 14).
Human data:
No data available.
Justification for classification or non-classification
Oral:
Based on Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP), chloro-cyano-p-tolyl-imidazole was classified as harmful if swallowed (Xn, R22; cat 4, H302).
Inhalation:
Based on Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP), chloro-cyano-p-tolyl-imidazole was not classified for acute inhalative toxicity.
Dermal:
Based on Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP), chloro-cyano-p-tolyl-imidazole was not classified for acute dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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