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Diss Factsheets
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EC number: 268-596-7 | CAS number: 68130-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial plants: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 208 (Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EEC Directive 79/831 "Higher Plant Growth Test"
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- no
- Species:
- Avena sativa
- Plant group:
- Monocotyledonae (monocots)
- Details on test organisms:
- - Common name: oat
- Species:
- Lycopersicon esculentum
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- - Common name: tomato
- Species:
- Raphanus sativus
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- - Common name: radish
- Test type:
- early seedling growth toxicity test
- Study type:
- other: not reported
- Substrate type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 2 wk
- Remarks:
- The test was finished at least two weeks after five of the control seedlings have emerged.
- Key result
- Species:
- Avena sativa
- Duration:
- 2 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Key result
- Species:
- Lycopersicon esculentum
- Duration:
- 2 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 300 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Key result
- Species:
- Lycopersicon esculentum
- Duration:
- 2 wk
- Dose descriptor:
- LOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Key result
- Species:
- Raphanus sativus
- Duration:
- 2 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 300 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Key result
- Species:
- Raphanus sativus
- Duration:
- 2 wk
- Dose descriptor:
- LOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Endpoint:
- toxicity to terrestrial plants: long-term
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Referenceopen allclose all
The test was finished 2 weeks after five of the control seedlings have emerged in the control. Lycopersicon esculentum and Raphanus sativus were more sensitive with a NOEC of 300 mg/kg soil dw compared to Avena sativa with a NOEC of 1000 mg/kg soil dw.
Description of key information
No studies on long-term terrestrial toxicity are available for this substance.The substance is predicted to be biodegradable therefore, no chronic exposure of terrestrial organisms is expected. A terrestrial plant toxicity test (short-term, OECD 208, Klimisch 4) with the read-across substance, CAS-No. 68002-79-9, is available, indicating no toxicity (NOEC = 300-1000 mg/kg soil dw, LOECs = 1000 mg/kg soil dw).
.
As discussed in ECHA Decision number CCH-D-2114343360-61-01/F, ECHA notes that additional toxicity testing on fish and aquatic invertebrates is being requested as part of the present Decision and the results of these tests may subsequently allow the derivation of PNECwater. If the results allow the subsequent derivation of a PNECwater, the Registrant may consider the ITS as recommended in section R.7.11.6., Chapter R.7c of the ECHA Guidance on information requirements and chemical safety assessment (May 2008), and determine the need for further testing on terrestrial organisms. In this case it may be possible to waive the corresponding terrestrial toxicity tests by including a justified argument for adaptation of Annex IX, 9.4.3. and Annex X, 9.4.6. or of Annex IX, 9.4.1. and Annex X, 9.4.4. in the registration dossier.
As discussed above, the Daphnia study is still in progress due to significant analytical issues. Once the study is completed, then the ITS will be evaluated, and determined if these studies are actually required. On the basis of existing study data, the substance is considered to be non-toxic and biodegradable. Structural analogues do not show toxicity, nor does existing study data on soil micro-organisms. The registrant considers that it is highly likely that the ITS will demonstrate this fact. Therefore a decision on whether to conduct these tests or not will be taken once the ITS investigation can be completed.
Key value for chemical safety assessment
Additional information
No studies on long-term terrestrial toxicity are available for this substance. The substance is predicted to be biodegradable therefore, no chronic exposure of terrestrial organisms is expected. Furthermore, a terrestrial plant toxicity test (short-term, OECD 208) with the read-across substance, CAS-No. 68002-79-9, is available, indicating no toxicity (NOEC = 300-1000 mg/kg soil dw, LOECs = 1000 mg/kg soil dw). In addition, fatty acid esters are readily metabolised to fatty acids and alcohols; these components naturally occur in sediment and soils, are part of physiological pathways and can be used as energy source.
A report justifying the read-across approach is included in IUCLID Chapter 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.