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EC number: 431-840-1 | CAS number: 87010-29-5 OXIPROPAZON; OXYPROPAZON
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study + GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-(3-hydroxypropyl)oxazolidin-2-one
- EC Number:
- 431-840-1
- EC Name:
- 3-(3-hydroxypropyl)oxazolidin-2-one
- Cas Number:
- 87010-29-5
- Molecular formula:
- C6 H11 N O3
- IUPAC Name:
- 3-(3-hydroxypropyl)oxazolidin-2-one
- Test material form:
- other: viscous liquid
- Details on test material:
- - Name of test material (as cited in study report): Oxypropazone
- Physical state: Light yellowish, viscous liquid
- Analytical purity: 96.5%
- Lot/batch No.: #120446/7.12.90
- Stability under test conditions: According to information from the sponsor, the test substance was stable throughout the experimental period
- Storage condition of test material: The test substance was kept in a closed container at room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Russian white
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ASTA Pharma AG, Bielefeld
- Age at study initiation: Males 7 and 9 months, female 7 months
- Weight at study initiation: Males 2.47 kg and 2.59 kg, female 2.56 kg
- Housing: stainless steel cages woth grating floor, one animal per cage
- Diet: approximately 120 g/day/animal, Standard diet, sniff K, Special diet for rabbits
- Water: ad libitum
- Acclimation period: Animals were kept one day under test conditions before application of the test substance
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5-24
- Humidity (%): 40-70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 4 h
- Observation period:
- Rabbits were score 1, 24, 48, 72 h and 3 days after test substance application
- Number of animals:
- three (two males, one female)
- Details on study design:
- TEST SITE
0.5 ml of the test substance was given on the left slte of the vertebral colunn. The site of application vas covered with a patch (6,25 cm2) conslsting of the following layers:
1. cellulose gauze
2. artificial wool coated wlth natural rubber
3. synthetic film glue
4. aluninium foi1.
Tbe opposlte area of the dorsal skin was treated in the same way but without test substance (control site). A bandage wrapped several times around the trunk (Acrylastic No. 2408, width 8 cm) provlded a complete occlusion. After the end of the exposition time remaining (4h) test material was gently washed off as far as possible.
SCORING SYSTEM:
The Draize method was used to assess the irrtiation score qualitatively (Erythema and edema) and quantitatively (values 0-4); furthermore, attention was given to the occurence of further skin reactions (e.g. corrosive effects) and to clinical symptoms (systemic toxic effects).
The arithmetical mean values of the individual grades obtained fron the skin areas at observation times 1, 24, 48 and 72 hours were
calculated - separately for erythena/eschar and edema formation. The irritation index is represented by the sum of these tvo mean values,
A corresponding gradatlon was allocated to this index by the folloving scheme using a modified method according to Gilman et al.
Index Ranges
0.0 0.5 0.6 3.0
3.1 s.0
5.1 8.0
Gradation
non-irritant
slightly irritant
noderately irritant
severely irritant
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- mean score
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- mean score
- Time point:
- other: 24, 48,72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48,72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- During the observation neither edema nor erythema have been detected. The primary Irritation index is 0.0, the gradation result based on Gilman is "non-irritant"
- Other effects:
- Systemic toxic effects could not be detected. The general condition of the test animals was not affected
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item did not produce skin irritation in rabbits in an OECD404 guideline study
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