Registration Dossier
Registration Dossier
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EC number: 287-634-3 | CAS number: 85566-24-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (< 0.02 mg/L at 20 °C, pH 6.3).
Key value for chemical safety assessment
Additional information
85566-24-1) to aquatic invertebrates are available, in accordance
to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the
structurally related source substance Fatty acids, C8-10, C12-18-alkyl
esters (CAS 95912-86-0) was conducted. The source substance is
representative to evaluate the long-term toxicity of the target
substance to aquatic invertebrates. The target substance is
characterized as an ester of mainly C14 fatty acid/C14 alcohol, C16
fatty acid/C14 alcohol and C16 fatty acid/C16 alcohol. The source
substance is structurally very similar to the target substance. Fatty
acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) is a UVCB substance
consisting of mainly C8-C10 fatty acids esterified with C12-C14 alcohol.
This read-across is justified in detail in the overall summary (IUCLID
Section 6.1) and within the analogue justification in IUCLID Section 13.
In this case of read-across, the best suited (highest degree of
structural similarity, nearest physico-chemical properties) read-across
substance was used for the assessment.
The study with the read-across substance fatty acids, C8-10,
C12-18-alkyl esters (CAS 95912-86-0) was performed according to OECD 211
(GLP) (Salinas, 2013). Daphnia magna was exposed to a nominal loading
rate of 10 mg/L (Water Accommodated Fraction). Chemical analysis of the
test substance concentrations was not possible since no suitable
analytical method could be developed to detect the test substance. No
effects on reproduction of D. magna were observed up to the water
solubility limit (< 0.05 mg/L) resulting in a NOELR (21 d) ≥ 10 mg/L.
Based on the available results from one structurally related read-across
substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5)
which is characterized by a similar ecotoxicological profile and
comparable structure, it can be concluded that Fatty acids, C14-18,
C14-18-alkyl esters will not exhibit long-term effects to aquatic
invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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