Registration Dossier
Registration Dossier
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EC number: 632-673-7 | CAS number: 26033-20-5
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 Oct 2020 - 21 Nov 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- March 04, 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 27, 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 3-phenyl-1H-pyrazole-4-carbaldehyde
- EC Number:
- 632-673-7
- Cas Number:
- 26033-20-5
- Molecular formula:
- C10H8N2O
- IUPAC Name:
- 3-phenyl-1H-pyrazole-4-carbaldehyde
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch (Lot) Number: M19LD3723
- Purity/Composition: 103.6%
- Purity/Composition correction factor: 1.0
- Purity test date : 2020-05-04
- Expiry date: 11 November 2021 (retest date)
- Physical Description: Light yellow powder
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.382 g/L
- Conc. based on:
- test mat.
- Remarks:
- The water solubility of a test item is specified by the saturation mass concentration of the test item in water at a given temperature and is expressed in g/L or equivalent.
- Temp.:
- 20 °C
- pH:
- > 6.9 - < 7
- Details on results:
- The maximum difference of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analyzed concentrations.
No test item was detected in the pretreated sample from the blank water mixture.
Any other information on results incl. tables
Water Solubility of the Test Item
Stirring time | Analyzed concentration | Mean | Maximum difference | pH |
|
|
|
|
|
24 | 0.365 | 0.382 | 11 | 7.0 |
|
|
|
|
|
48 | 0.375 |
|
| 7.0 |
|
|
|
|
|
72 | 0.407 |
|
| 6.9 |
|
|
|
|
|
Applicant's summary and conclusion
- Conclusions:
- The flask method was applied for the determination of the water solubility of JNJ-39125190-AAA (T003897).
The water solubility of the test item at 20°C was 0.382 g/L.
The pH of the aqueous samples was 6.9 and 7.0.
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