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EC number: 601-093-6 | CAS number: 111453-32-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412, L9
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- rac-5-Amino-N-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamic acid
- EC Number:
- 601-093-6
- Cas Number:
- 111453-32-8
- Molecular formula:
- C11 H11 I3 N2 O5
- IUPAC Name:
- rac-5-Amino-N-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamic acid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances):
- Method: For the definitive test, a stock suspension of 10.0015 g/L was prepared by dissolving the test substance in test medium at room temperature. This solution was neutralized to pH-7 with 1 M NaOH.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Common name: green algae
- Source: Culture Collection of Algae and Protozoa, Ambleside, Cumbria. United Kingdom on 1990.11.16; This strain was malntained on sloped agar tubes In the light at room temperature tor 2 weeks. After this perlod the sloped agar tubes are stored at 4 °C until required.
- Age of inoculum (at test initiation): fresh
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 23.4 - 24.7 °C
- pH:
- 8.3 - 9.3
- Nominal and measured concentrations:
- Nominal: 0, 10, 100, 1000, 10000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL Erlenmayer flasks (sterilized)
- Initial cells density: 2.0 E+04 cells/mL
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 6
GROWTH MEDIUM
- Standard medium used: yes
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Photoperiod: continuous light
- Light intensity and quality: 60 - 120 µEm-2*s-1
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: Cell concentrations were determined photometrically (UV/VIS, 436 nm)
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrations
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Observation of abnormalities (for algal test): no - Results with reference substance (positive control):
- ErC50 (72 h): 1.00 mg/L
EbC50 (72 h): 0.37 mg/L - Reported statistics and error estimates:
- The EC10,50 values were computed from the best fitted line (Ieast-squares method) through the points given by the probit of the percentage of inhibition and the logarithm of the concentration of the test substance. The EC50 value calculated for the area under the growth curve Is termed EbC50 (0-72 h), whereas the EC50 value calculated for the specific growth rate is termed ErC50. Confidence limits were computed on the basis of Fleller's theorem (4.2). All computations were performed using the Akzo programme ‘AIgal’ (version 3.3) made In SAS (4.3).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The ErC50 (72 h) of Tamip monoamid (ZK39.211) to green algae was higher than 10 g/L.
- Executive summary:
Desmodesmus subspicatus were incubated over a period of 72 h to ZK 39.211 at concentrations from 0.01 - 10 g/L. The cell density was determined by extrapolating the measured chlorophyll concentration. Chlorophyll was analysed at 0, 24, 48 and 72 hours by means of a spectrophotometer and values were recalculated for cell density by a calibration factor. Biomass and specific growth rate was calculated. Therefore, no values tor the concentrations of ZK39211 (TAMIP-monoamide) leading to a 10% or 50% reduction in specific growth rate (ErC10 or ErC50) or to a 10% or 50% reduction in growth over the 72-hour period [EbC10 or EbC50 (0-72 hours)] could be calculated. The reference compound potassium dichromate had an ErC50 and EbC50 of 1.0 and 0.37 mg/L, respectively.
The cell density was inhibited up to 16% at the highest concentration. Therefore, the EC50 (72 h) was higher than 10 g/L.
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