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EC number: 485-320-2 | CAS number: 221667-31-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Sep - 13 Oct 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 217 (Soil Microorganisms: Carbon Transformation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on preparation and application of test substrate:
- APPLICATION OF TEST SUBSTANCE TO SOIL
- Method: Sieved soil (2 mm) was treated with either 10 g ground quartz sand/kg dry weight soil (control) or a mixture of quartz sand and AE 0001789 tech. (AE 0001789 00 1C97 0005) (0.21 mg or 1.07 mg/kg dry weight soil). The samples were mixed with pulverized lucerne-grass-green meal (5 g/kg dry weight soil) and quartz sand in 3 liter polyethylene containers by rolling on a gyrowheel mixer (Elte 650, J. Engelsmann AG, Ludwigshafen, Germany) for 15 min at 50 rpm. - Test organisms (inoculum):
- soil
- Total exposure duration:
- 28 d
- Test temperature:
- 20 ± 2 °C
- Details on test conditions:
- TEST SYSTEM
- Testing facility: Laboratory
- Test container (type, material, size): 500 mL brown glass bottles and these were closed with parafilm
- Amount of soil: 350 g dry weight
- No. of replicates per concentration: 3
- No. of replicates per control: 3
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Geographical reference of sampling site: The soil used is from Field plot F on the Bayer CropScience AG's experimental farm Laacherhof, Germany. The Laacherhof experimental farm is located at a latitude of 51 °4' north and a longitude of 6°55' east.
- History of site: experimental farm Laacherhof, Germany with grass, summer wheat, winter rye, winter barley, winter wheat
- Vegetation cover: Yes
- Treatments with pesticides or fertilizers: Plant protection chemicals have not been used on this field since 1981. The plot has been under grass and has not been treated with fertilizers since 1996
- Accidental contamination: No
- Depth of sampling: 0-20 cm
- Soil taxonomic classification: loamy sand
- Storage (condition, duration): It was passed through a 2 mm sieve and stored at 4 ± 2 °C until used (according to guideline)
- Initial microbial biomass as % of total organic C: 1.3 - Nominal and measured concentrations:
- In this study, the equivalents of 0 kg (Control), 0.16 kg and 0.8 kg of AE 0001789 tech./ha were added to samples of an agricultural soil (0, 0.21 and 1.07 mg/kg dry weight soil).
- Reference substance (positive control):
- yes
- Remarks:
- Sodium chloride
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1.07 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- respiration rate
- Remarks on result:
- other: (equivalent to 0.8 kg product/ha)
- Validity criteria fulfilled:
- yes
- Remarks:
- See Table 1 in "Any other information on results incl. tables".
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Sep - 14 Oct 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on preparation and application of test substrate:
- AMENDMENT OF SOIL
- Type of organic substrate:
Substrate: Lucerne-grass-green meal
Source of Substrate: Hoeveler Kraftfutter, 40764 Langenfeld
Content: 40.6 % Ctotal, 0.05 % Cinorg, 2.5 % N
APPLICATION OF TEST SUBSTANCE TO SOIL
- Method: Sieved soil (2 mm) was treated with either 10 g ground quartz sand/kg dry weight soil (control) or a mixture of quartz sand and AE 0001789 tech. (AE 0001789 00 1C97 0005) (0.21 mg or 1.07 mg/kg dry weight soil). The samples were mixed with pulverized lucerne-grass-green meal (5 g/kg dry weight soil) and quartz sand in 3 liter polyethylene containers by rolling on a gyrowheel mixer (Elte 650, J. Engelsmann AG, Ludwigshafen, Germany) for 15 min at 50 rpm. - Test organisms (inoculum):
- soil
- Total exposure duration:
- 28 d
- Test temperature:
- 20 ± 2 °C
- Details on test conditions:
- TEST SYSTEM
- Testing facility: Laboratory
- Test container (type, material, size): brown glass bottles and these were closed with parafilm
- Amount of soil: 300 g dry weight
- No. of replicates per concentration: 3
- No. of replicates per control: 3
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Geographical reference of sampling site: The soil used is from Field plot F on the Bayer CropScience AG's experimental farm Laacherhof, Germany. The Laacherhof experimental farm is located at a latitude of 51 °4' north and a longitude of 6°55' east.
- History of site: experimental farm Laacherhof, Germany with grass, summer wheat, winter rye, winter barley, winter wheat
- Vegetation cover: Yes
- Treatments with pesticides or fertilizers: Plant protection chemicals have not been used on this field since 1981. The plot has been under grass and has not been treated with fertilizers since 1996
- Accidental contamination: No
- Depth of sampling: 0-20 cm
- Soil taxonomic classification: loamy sand
- Storage (condition, duration): It was passed through a 2 mm sieve and stored at 4 ± 2 °C until used (according to guideline)
- Initial microbial biomass as % of total organic C: 1.3 - Nominal and measured concentrations:
- In this study, the equivalents of 0 kg (Control), 0.16 kg and 0.8 kg of AE 0001789 tech./ha, corresponding to 0.21 mg and 1.07 mg AE 0001789 tech. (AE 0001789 00 1C97 0005)/kg dry weight soil, were added to samples of an agricultural soil.
- Reference substance (positive control):
- yes
- Remarks:
- Sodium chloride
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1.07 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- nitrate formation rate
- Remarks on result:
- other: (equivalent to 0.8 kg product/ha)
- Validity criteria fulfilled:
- yes
- Remarks:
- See Table 1 in "Any other information on results incl. tables".
Referenceopen allclose all
Conclusions:
During the 28-day tests, 0.16 kg AE 0001789 tech. / ha and the 5-fold overdose of the test item had no influence on carbon transformation after addition of glucose to a loamy sand.
Table 1: Validity criteria for OECD 217 (2000)
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
The variation between replicate control samples should be less than ± 15%. |
The highest coefficient of variation (CV) between carbon dioxide concentration in replicate control samples was 5.5 %. |
yes |
During the 28-day test, in a soil amended with lucerne-grass-green-meal (5 g/kg), it was found that 0.21 mg AE 0001789 tech./kg dry weight soil (equivalent to 0.16 kg product/ha) and the 5-fold field rate of the compound had no influence on nitrogen transformation in a loamy sand. In none of the time intervals analysed during the 28 day exposure the difference in the daily nitrate-N rates exceeds the trigger value of 25 %.
Conclusions: During the 28-day test, the recommended field rate of AE 0001789 tech. and the 5-fold field rate of the compound had no influence on nitrogen transformation in a loamy sand soil amended with lucerne-grass-green meal.
Table 1: Validity criteria for OECD 216 (2000)
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
The variation of nitrate concentrations between replicate control samples should be less than ± 15%. |
The variation of nitrate concentrations between replicate control samples should be less than≤10%. |
yes |
Description of key information
NOEC (28 d): ≥1.07 mg/kg soil dw (nominal, soil microflora, OECD 216)
NOEC (28 d): ≥1.07 mg/kg soil dw (nominal, soil microflora, OECD 217)
Key value for chemical safety assessment
- Long-term EC10 or NOEC for soil microorganisms:
- 1.07 mg/kg soil dw
Additional information
Based on one carbon (M-261945-01-1) and one nitrogen (M-262722-01-1) transformation test which were conducted according to OECD 217 and OECD 216, it can be concluded that, the substance has no negative influence on the turnover of organic carbon and nitrogen in soil. During the 28-day tests, the recommended field rate of the substance (0.21 mg/kg soil dw) and the 5-fold rate of the compound (1.07 mg/kg soil dw) had no effects >25% on nitrogen transformation in a loamy sand soil amended with lucerne-grass-green meal or the carbon transformation after addition of glucose to a loamy sand compared to the controls.
Thus, no risk to soil microorganisms is to be expected from the use of the substance as a safener in a formulation under practical field conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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