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EC number: 224-594-8 | CAS number: 4422-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
pH
Administrative data
- Endpoint:
- acidity / alkalinity
- Remarks:
- (1) pH and/or (2) acidity/alkalinity per OECD TG 122: Determination of pH, Acidity and Alkalinity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15-03-2022 to 28-04-2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
Materials and methods
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Benzene-1,3,5-tricarbonyl trichloride
- EC Number:
- 224-594-8
- EC Name:
- Benzene-1,3,5-tricarbonyl trichloride
- Cas Number:
- 4422-95-1
- Molecular formula:
- C9H3Cl3O3
- IUPAC Name:
- benzene-1,3,5-tricarbonyl trichloride
- Test material form:
- solid
- Details on test material:
- - Physical state: (1) White to pale yellow liquid could crystallize (provided by the Sponsor) ; (2) White to pale yellow crystalline powder with some agglomerations (determined by test facility)
- Storage condition of test material: In refrigerator (2-8°C) protected from light
- Other: Two physical states/physical descriptions were provided by the sponsor and/or the test facility (upon test item receipt) ; applicant assessment indicates that the melting point is low (< 40°C) and therefore is responsible for the difference in descriptions
Constituent 1
Reagents
- Reagent:
- NaOH solution
Titration of acidity and alkalinity
- Details on titrant used:
- - Volume of titrant used: 11.6070 mL 0.2 N NaOH solution for acidity measurement (i.e. 0.2 mol/L NaOH solution)
- Titer of titrant used: See above.
- Other: At 0.1%w/v concentration in water, since the test item did not fully dissolve in water and, thus, could not be titrated it was pre-treated with 10 mL acetone prior to adding 100 mL deionised water. The mixture was left stirring overnight to ensure the test item was fully dissolved.
Results and discussion
pH value
- Key result
- pH value:
- 1.97
- Temp.:
- 20 °C
- Concentration:
- 1 other: %w/v dilution in water
- Remarks on result:
- other: mean (n=2) pH ; pH range 1.96 to 1.98 ; temperature: 20 ± 1 °C ; 1% (w/v) dilution in water per OECD TG 122
Acidity or alkalinity
- Key result
- Acidity or alkalinity:
- acidity
- Value:
- 111
- Remarks on result:
- other: units: %m/m Acidity, calculated as H2SO4 ; concentration: 0.1%w/v dilution into water; test item pre-treated with 10 mL acetone prior to dilution in 100 mL water due to limited solubility per OECD TG 122
Any other information on results incl. tables
pH:
The pH values in duplicate were measured using the combined glass electrode and the pH was determined to be 1.96, and 1.98, respectively. The mean pH was 1.97.
Acidity:
The acidity of test item calculated as H2SO4, was determined to be 111 %m/m calculated as H2SO4 when the test item was pre-treated with 10 mL acetone prior to diluting in 100 mL deionised water. The amount of titrant 0.2 N sodium hydroxide solution used was 11.6070 mL
Applicant assessment indicates, when added to water the test item forms a highly acidic solution of pH < 2.0.
Applicant's summary and conclusion
- Conclusions:
- The pH values in duplicate were measured using the combined glass electrode and the pH was determined to be 1.96, and 1.98, respectively. The mean pH was 1.97. The acidity of test item calculated as H2SO4, was determined. The amount of titrant used 0.2 N sodium hydroxide solution was 11.6070 mL. The acidity of the test item was determined to be 111 %m/m calculated as H2SO4 when the test item was pre-treated with 10 mL acetone prior to diluting in 100 mL deionised water.
- Executive summary:
The pH and/or acidity/alkalinity properties of the test item was determined in a OECD TG 122 study using electrometric end point determination under GLP. The pH was measured using a 906 Titrando and a combined glass electrode using a test item 1%w/v aqueous solution at 20 ± 1 °C. The pH meter was calibrated using three commercially available buffer solutions pH 4, pH 7 and pH 10. At the start and at the end of the measurements, pH of the buffer solution at pH 7 was measured to ensure proper performance of the pH meter. The determination of the acidity or alkalinity of the test item was performed if the pH of the test item or a 1% (w/v) dilution in water is < 4 or > 10 and if the test item is sufficiently soluble in water or acetone/water mixtures. 0.1029 g test item was accurately weighed into a titration vessel and dissolved in 100 mL deionised water under stirring. Since the test item did not fully dissolve in water and, thus, could not be titrated it was pre-treated with 10 mL acetone prior to adding to the 100 mL deionised water. The mixture was left stirring overnight to ensure the test item fully dissolved. After homogenization, the solution was titrated electrochemically to pH 7 at ambient temperature while stirring. To achieve this, a 0.2 N standardized sodium hydroxide solution (t mL) was used at 20 ± 1 °C. The test was performed in duplicate (n=2). The pH values in duplicate were measured using the combined glass electrode and the pH was determined to be 1.96, and 1.98, respectively. The mean pH was 1.97. The acidity of test item calculated as H2SO4, was determined. The amount of titrant used 0.2 N sodium hydroxide solution was 11.6070 mL. The acidity of the test item was determined to be 111 %m/m calculated as H2SO4 when the test item was pre-treated with 10 mL acetone prior to diluting in 100 mL deionised water.
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