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EC number: 241-155-6 | CAS number: 17090-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- sodium 2-amino-3-carboxypropanoate
- Cas Number:
- 323194-76-9
- Molecular formula:
- C4H7NO4.xNa
- IUPAC Name:
- sodium 2-amino-3-carboxypropanoate
- Test material form:
- solid: particulate/powder
- Details on test material:
- Name: L-aspartic acid, sodium salt monohydrate 1
Batch/Lot number: Z201125/ VG29848563
CAS number: 323194-76-9
Anhydrous substance name: L-aspartic acid, sodium salt, CAS: 17090-93-6
Appearance: Solid, white, crystalline powder
Purity: 98%
Expiry date: 24 November 2022
Storage conditions: Room temperature (15-25 ºC), protected from humidity (tight closed
container)
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- ca. 693.07 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 0.521 g/L
- Incubation duration:
- ca. 3 d
- Temp.:
- 20 °C
- pH:
- >= 7.08 - <= 7.09
Applicant's summary and conclusion
- Conclusions:
- Solubility in water of the Test item at 20.0 ± 0.5 oC and at pH ranging 7.08 – 7.09 is 693.07 g/l. (EC A.6./OECD 105)
- Executive summary:
Solubility in water of the Test item at 20.0 ± 0.5 oC and at pH ranging 7.08 – 7.09 is 693.07 g/l. (EC A.6./OECD 105)
Description of the method
The study of the determination of ASPARTIC ACID SODIUM SALT MONOHYDRATE solubility in water at one pH value using shake flask method was carried out according to the method EC A.6. COUNCIL REGULATION (EC) No 440/2008 (Method A.6. Water solubility; p.57) and (EC) No 260/2014 (Method A.6. Water solubility; p.3) which is in conformity with OECD Guideline 105 and concluded in SPO/BS/08/b, edition 6.
3.5.2. Course of the study
The preliminary test of a small sample (~ 0.1g) of Test item was performed in a 10 ml measuring cylinder, in gradually increased volume of distilled water. Starting from 0.1 g of water after addition of the sample, the solution was vigorously mixed for 10 minutes and it was visually determined if insoluble parts of Test item was in solution. In that way, an approximate solubility of Test item was determined at the solvent volume in which the whole substance was dissolved.
About 23 g of test item was weighed into each of three 50 ml glass vessels fitted with glass stoppers. 20 ml of double distilled water was added to each vessel. The volume of water was chosen on the basis of the analytical method and solubility range.
These closed vessels were agitated in an incubator at 30 oC with magnetic stirrers.
After one day, one of the flasks was equilibrated for 24 h at the test temperature (20 ± 0.5) oC with occasional shaking. The other two flasks were treated similarly after initial equilibration at 30 ± 1 oC for two and three days, respectively.
The samples taken during saturation were separated using a vial-centrifuge to give the clear liquid phase and the concentration of test substance in the clear solvent phase was determined by a suitable HPLC method.
If the concentrations measured in at least the two last flasks did not differ by more than 15%, the test was satisfactory. If the results from vessels 1, 2 and 3 show a tendency of increasing values, the whole test should be repeated using longer equilibration times.
The pH of each sample was measured using a calibrated pH electrode (SPO/BS/24/t, edition 3).
The density of the solution was determined (SPO/BS/16/t, edition 2) to recalculate the analytical study results which were obtained in g/kg.
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