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EC number: 411-950-4 | CAS number: 96562-58-2 DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl (R)-2-(4-hydroxyphenoxy)propionate
- EC Number:
- 411-950-4
- EC Name:
- Methyl (R)-2-(4-hydroxyphenoxy)propionate
- Cas Number:
- 96562-58-2
- Molecular formula:
- C10H12O4
- IUPAC Name:
- methyl (2R)-2-(4-hydroxyphenoxy)propanoate
- Test material form:
- solid
- Details on test material:
- - Appearance: Brown solid
- Storage conditions of test material: Refrigerator
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: Male: 3.38 kg; females 2.84 kg
- Housing: Animals were housed individually in cages made of stainless steel with wire mesh walk floors (floor area 40 x 51 cm). There was no bedding in the cages but sawdust in the waste trays
- Diet: About 130 g per animal per day
- Water: About 250 mL tap water per animal per day
- Acclimation period: At least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20 to 24 °C
- Humidity: 30 to 70 % (relative)
- Air changes: Not specified; the animals were housed ln fully air-conditioned rooms
- Photoperiod: 12 hours of light / 12 hours of darkness (lights on 06:00 to 18:00)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3; 1 male and 2 female
- Details on study design:
- TEST SITE
- Area of exposure: Upper third of the back or flanks. Clipping of the fur took place at least 15 hours prior to the start of the study.
- Type of wrap if used: The solid test material was warmed to 70 °C until liquid. The undiluted material cooled to body temperature was applied to a test patch (2.5 x 2.5 cm) that was secured in position with a porous dressing (four layers of absorbent gauze and porous bandage).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): With Lutrol and Lutrol/water (1:1)
- Time after start of exposure: At the end of the 4 hour exposure period
OBSERVATION TIME POINTS
30 to 60 minutes after removal of the patches and 24, 48 and 72 hours after the beginning of the application.
SCORING SYSTEM:
Evaluation of erythema and oedema
0 = None
1 = Very slight
2 = Well defined
3 = Moderate to severe
4 = Severe to very severe
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.11
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- An erythema score of 1 was obtained for one of the female rabbits at the 24 hour observation. All other scores for erythema and all oedema scores were 0 at each time point.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU criteria
- Conclusions:
- Under the conditions of this study, the test material was determined to be not irritating to the skin of rabbits.
- Executive summary:
The skin irritation potential of the test material was investigated in accordance with the standardised guidelines OECD 404 and EU Method B.4 under GLP conditions.
The undiluted test material was applied to the skin of three New Zealand White rabbits in a semi-occlusive fashion for 4 hours. At the end of the 4 hour exposure period, the test material was removed with Lutrol and Lutrol/water (1:1). Animals were observed 30 to 60 minutes after removal of the patches and after 24, 48 and 72 hours after the beginning of the application and scored for erythema and oedema formation.
An erythema score of 1 was obtained for one of the rabbits at the 24 hour observation. All other scores for erythema and all oedema scores were 0 at each time point.
Under the conditions of this study, the test material was determined to be not irritating to the skin of rabbits.
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