Registration Dossier
Registration Dossier
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EC number: 700-169-7 | CAS number: 7646-67-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 April 2007 to 21 September 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.73
- Temp.:
- 20 °C
- pH:
- 7
- Conclusions:
- HEAA was found to have logPow value of -0.73 ( Pow = 0.19 ).
Reference
The detector calibration, for the n-octanol phase analysis, was found to be linear over the range 0 to 5 mg/l of standard solutions in acetone:n-octanol (95:5 v/v), with a regression coefficient of 0.9992.
The detector calibration, for the aqueous phase analysis, was found to be linear over the range 0 to 10 mg/l of standard solutions in acetone:water (99:1 v/v), with a regression coefficient of 0.9995.
It is acknowledged that samples E and F for the n-octanol phases fall outside of the prepared calibration range. These results, however, have been accepted as the samples fall within the demonstrated linear range for the aqueous samples. The response of the aqueous calibration standards was found to be comparable to that of the n-octanol calibration standards. The mean concentration of HEAA from the n-octanol stock solution was found to be 533.7 mg/l. The mean recovery of HEAA from the spikes prepared in n-octanol saturated water was found to be 103%.
No significant peaks were observed in the chromatograms of blank solutions, indicating that the analytical method was free from interference.
Description of key information
HEAA was found to have logPow value of -0.73 ( Pow = 0.19 ).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.73
- at the temperature of:
- 20 °C
Additional information
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