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EC number: 200-718-6 | CAS number: 69-89-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- Purity: > 99%
- Key result
- Water solubility:
- 15.84 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 20
- pH:
- 7
- Remarks on result:
- other: No pH reported; assumed to be neutral
- Conclusions:
- The water solubility of the test substance was determined to be 15.84 mg/L.
- Executive summary:
The water solubility of the test substance was performed by the shake-flask method, according to OPPTS 830.7840 and OECD TG 105 and EEC Test Method A6. Once each day for three consecutive days, a saturated solution of the test substance in water was prepared for a total of three preparations. Approximately 0.1 grams of test substance were weighed into separate vessels and 50 mL of distilled water was added. After each preparation, the flasks were tightly stoppered, then placed into a water bath and agitated at a temperature of 30°C. The first prepared flask was agitated for 3 days; the second and third flask was agitated two days and one day, respectively. The start times were staggered, so all flasks would be ready for High Performance Liquid Chromatography (HPLC) on the same day. After this time, the flasks were removed from the water bath and re-equilibrated at the test temperature of 20°C for an additional 24 hours with occasional shaking. The solutions were then passed through a PTFE 0.20 µm syringe filter and the concentration was determined in duplicate by HPLC. At the beginning of the analysis, the HPLC was equilibrated until it gave a stable, consistent chromatogram. The standards and samples were injected at consistent time intervals in order to maintain a steady baseline. Solvent blanks, standards, and distilled water blanks were run, all samples were run in duplicate. The peak areas of the agitated samples were corrected to account for the distilled water blanks. Following up to 12 sample injections, a standard was run to confirm system stability and calibration. All calculations were performed using Excel with full precision. Minor differences found between the values were reported and those obtained if calculated manually. Statistical analysis was limited to the calculation of the mean and standard deviation. The water solubility of the test substance was determined to be 15.84 mg/L.
Reference
Water Solubility Determination
Linearity:
Standard Number | Concentration (mcg/mL) | Area |
Lin 1 | 1.6750 | 466.74713 |
Lin 2 | 3.3500 | 748.51031 |
Lin 3 | 5.0250 | 1027.11169 |
Lin 4 | 6.7000 | 1305.82690 |
Lin 5 | 10.0500 | 1931.6461 |
Lin 6 | 13.4000 | 2568.9241 |
Correlation Coefficient | 1.000 | |
Slope | 1.794E+02 | |
Intercept | 1.397E+02 |
Results:
Sample ID | Dilution Factor | Area (Counts) | Corrected Area (Counts) | % AI (Individual) |
Avg. (mg.ml) | Solubility (mg/L)
| |
|
|
|
|
| % AI Grand Avg. | SD | |
Distilled water blank |
| 96.81097 |
|
|
|
15.84 |
0.08
|
| 99.62799 |
|
|
| |||
F1 R1 | 2.5 | 1338.58240 | 1240.36292 | 16.01 |
15.92
| ||
F1 R1 | 2.5 | 1327.96802 | 1229.74854 | 15.88 | |||
F1 R2 | 2.5 | 1335.30127 | 1237.08179 | 15.97 | |||
F1 R2 | 2.5 | 1322.67529 | 1224.45581 | 15.81 | |||
F2 R1 | 2.5 | 1316.22058 | 1218.00110 | 15.73 |
15.77 | ||
F2 R1 | 2.5 | 1328.49817 | 1230.27869 | 15.88 | |||
F2 R2 | 2.5 | 1323.11133 | 1224.89185 | 15.81 | |||
F2 R2 | 2.5 | 1310.32678 | 1212.10730 | 15.65 | |||
F3 R1 | 2.5 | 1332.44934 | 1234.22986 | 15.93 |
15.83 | ||
F3 R1 | 2.5 | 1302.43347 | 1204.21399 | 15.55 | |||
F3 R2 | 2.5 | 1331.90027 | 1233.68079 | 15.93 | |||
F3 R2 | 2.5 | 1330.53357 | 1232.31409 | 15.91 |
Note: Average Distilled Water Blank Response area = 99.62799
Description of key information
OECD Guideline 105
Key value for chemical safety assessment
- Water solubility:
- 15.84 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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