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Diss Factsheets
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EC number: 209-513-6 | CAS number: 583-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The 2-methylcyclohexanone was screened for acute toxicity: oral, dermal and through inhalation (Smyth et al., 1969):
• oral: 2-methylcyclohexanone LD50: =1370 - 2868 mg/kg bw
• dermal: 2-methylcyclohexanone LD50: 1637 mg/kg bw
• inhalation: 2-methylcyclohexanone LD50: 2800 ppm.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- No description of the guideline available
- GLP compliance:
- not specified
- Species:
- rat
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 1 370 - <= 2 868 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated value considering LD50 value reported in mL/Kg, converted to mg/Kg by considering density
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 1.48 - <= 3.1 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: value as reported in the study
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The 2-methylcyclohexanone and the source cyclohexanone show similar single oral toxicity in rats, with a slight lesser toxic dose for the target compound 2-methylcyclohexanone (Smyth et al., 1969):
• 2-methylcyclohexanone LD50: 2.14 (1.48-3.10) ml/kg
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 370 - 2 868 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- No description of the guideline available
- GLP compliance:
- not specified
- Species:
- rat
- Sex:
- not specified
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 2 800 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 50%
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- 2-methycyclohexanone has an acute inhalative LC50 of 2800 ppm. As a result, the substance meets the criteria for classification for Category 4 according to Regulation (EC) No 1272/2008, Annex I section 3.1.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 2 800 ppm air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- No description of the guideline available
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- <= 1 637 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated value considering LD50 value reported in mL/Kg, converted to mg/Kg by considering density
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1.77 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: value as reported in the study
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- 2-methycyclohexanone has an acute dermal LD50 of 1.77 mL/Kg. As a result, the substance meets the criteria for classification for Category 1 according to Regulation (EC) No 1272/2008, Annex I section 3.1.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 637 mg/kg bw
Additional information
Justification for classification or non-classification
Acute Toxicity, oral: 2-methycyclohexanone has an acute oral LD50 of ≤ 2 000 (acute oral LD50 = 1370 mg/kg bw - 2868 mg/kg bw). As a result, the substance meets the criteria for classification for Category 4 according to Regulation (EC) No 1272/2008, Annex I section 3.1.
Acute Toxicity, dermal: 2-methycyclohexanone has an acute dermal LD50 ≤ 2 000 (acute dermal LD50 =1637 mg/Kg bw). As a result, the substance meets the criteria for classification for Category 4 according to Regulation (EC) No 1272/2008, Annex I section 3.1.
Acute Toxicity, inhalative: 2-methycyclohexanone has an acute inhalative LC50 of 2800 ppm. As a result, the substance meets the criteria for classification for Category 4 according to Regulation (EC) No 1272/2008, Annex I section 3.1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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