Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
The widespread use of enzymes has been followed by investigations relevant for ecotoxicity. Investigations are mainly performed to establish knowledge on short-term aquatic toxicity and on the rate of biodegradability of the enzyme. Algae growth inhibition tends to be the most sensitive aquatic endpoint reported for enzyme preparations in the literature with EC50 concentrations ranging from 99 to >1,000 mg/L [2]. The published data support that enzyme preparations are not highly inhibitory to the growth of aquatic algae and non-proteolytic enzymes, such as transaminase, should not be classified as harmful or toxic to the environment [1].
[1] Enzymes REACH Consortium (2010). Data waiving argumentation for technical enzymes.
[2] HERA Human and environmental risk assessment on ingredients of household cleaning products - alpha-amylases, cellulases and lipases. 2005.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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