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EC number: 701-402-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30.10.2003 - 03.04.2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Nederland GLP
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- EC Number:
- 243-528-9
- EC Name:
- Dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- Cas Number:
- 20120-33-6
- Molecular formula:
- C6H14NO5P
- IUPAC Name:
- dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- Reference substance name:
- Dimethyl (3-amino-3-oxopropyl)phosphonate
- EC Number:
- 219-765-9
- EC Name:
- Dimethyl (3-amino-3-oxopropyl)phosphonate
- Cas Number:
- 2526-69-4
- Molecular formula:
- C5H12NO4P
- IUPAC Name:
- dimethyl (3-amino-3-oxopropyl)phosphonate
- Test material form:
- liquid: viscous
- Details on test material:
- Technical product
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 137244-407
- Expiration date of the lot/batch: July 2004
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeding facility, Jai research foundation, India
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 9 weeks old at the time of dosing
- Weight at study initiation: 173-190 g
- Fasting period before study: Overnight
- Housing: 3 animals/cage; Polypropylene rat cages covered with stainless steel grid top
- Diet: Rat pellet diet (Amrut brand) manufactured by Pranav Agro Industries Limited, Pune, Maharashtra, India, ad libitum
- Water: ad libitum
- Acclimation period: 5 days (step 1) and 8 days (step 2) prior to commencement of dosing.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 24
- Humidity (%): 63 - 66
- Air changes (per hr): 17
- Photoperiod: 12 h artificial light and 12th darkness, light hours being 06:00 - 18:00 h
IN-LIFE DATES: From: 17 Feb 2004 To: 5 March 2004
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg
DOSAGE PREPARATION (if unusual):
Required quantities of Aflammit KWB were weighed on a calibrated weighing balance in glass beakers. The test substance was then dissolved in a small volume of distilled water and transferred in to calibrated 10 mL measuring cylinder. The beaker was rinsed twice with small volume of distilled water and transferred into the measuring cylinder. Finally, the total volume of the dose solution was made up to 10 mL with distilled water and mixed thoroughly.
CLASS METHOD
- Rationale for the selection of the starting dose: Not provided - Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 6 females in two groups of three
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation for overt signs of toxicity and mortality at 30 minutes, 1, 2, 3, 4, hours and once per hour thereafter, after dosing (on day 0). Subsequently, the animals were observed twice a day for morbidity and mortality for a period of 14 days following oral dosing. The clinical signs were recorded once a day. Individual body weights were recorded prior to dermal application (day 0) and on days 7 and 14 following dermal application. In addition, observations such as mortality and gross pathology was carried out. - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No intercurrent deaths occurred during the course of the study.
- Clinical signs:
- other: No clinical signs were observed in the animals treated with Aflammit KWB at the dose level of 2000 mg/kg body weight.
- Gross pathology:
- External examination of animals sacrificed at the termination did not reveal any pathological lesion/abnormality
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral median lethal dose (LD50) of DMPPA_701-402-5 in Wistar rats is considered to be greater than 5000 mg/kg body weight.
- Executive summary:
An acute oral toxicity study was carried out to assess the acute oral toxicity of Aflammit KWB (supplied by THOR GmbH, Landwehrstrasse I , 67346 Speyer, Germany) in Wistar rats. The rnethod followed was as per the guidelines of: OECD 423 "Acute Oral Åcute Toxic Class Method".
A selected group of rats comprising of 3 females were given a single dose of 2000 mg Aflammit KWB/kg body weight (step I). Since no mortality was another set of 3 female rats were given a single dose of 2000 mg Aflammit KWB/kg body weight after two days (step 2). Both sets of animals were observed daily for a period of 14 days after dosing. No mortality was observed at the dose level of 2000 mg Aflammit KWB/kg body weight in either set. Animals were starved overnight prior to dosing and upto three hours post dosing.
All animals were subjected to gross pathological examination at the end of the observation period.
The acute oral median lethal dose (LD50, cut off value) of Aflammit KWB in Wistar rats is 5000 mg/kg body weight by this test method. According to GHS Aflammit KWB/DMPAA can be classified into Category 5 or Unclassified.
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