Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 482-670-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The ability of neodymium tris (di-2-ethylhexylphosphate) to induce genetic damage was assessed in an in-vivo micronucleus assay performed according to internationally recognised guidelines and in compliance with GLP. This study was scored as validity 1 according to Klimisch criteria and thus considered as the key study.
No in-vitro assays are available, as it was technically impossible to perform the tests. Indeed, neodymium tris(di-2-ethylhexylphosphate) is not soluble in the vehicles usually used in in-vitro tests (water, dimethylsulfoxide, acetone, ethanol, tetrahydrofurane). During preliminary assays, no homogeneous suspension (to the naked eye) could be obtained in these vehicles at concentrations as low as 1 or 10 mg/mL to allow treatment in adequat conditions.
In a bone marrow micronucleus study performed according to OECD 474, EU B.12, EPA OPPTS 870.5395 and GLP (CIT report No. 33215 MAS, 2008), scored as validity 1 according to Klimisch criteria, three groups of five male and five female mice were given neodymium tris (di-2-ethylhexylphosphate) in corn oil at dose-levels of 500, 1000 and 2000 mg/kg/day by oral route, over a 2-day period (two treatments separated by 24 hours). Concurrent vehicle control (corn oil) and positive control (cyclophosphamide) were tested in parallel.
The animals were killed 24 hours after the last treatment.
For each animal, the number of the micronucleated polychromatic erythrocytes (MPE) was counted in 2000 polychromatic erythrocytes. The polychromatic (PE) and normochromatic (NE) erythrocyte ratio was established by scoring a total of 1000 erythrocytes (PE + NE).
Neither mortality, nor clinical signs were observed in the animals of either sex at any dose-levels.
The mean values of MPE as well as the PE/NE ratio in the groups treated with the test item, were equivalent to those of the vehicle group. The vehicle and positive controls gave appropriate response, consistent with the historical data.
Under these experimental conditions, neodymium tris (di-2-ethylhexylphosphate) did not induce damage to the chromosomes or the mitotic apparatus of mice bone marrow cells after two oral administrations, at a 24-hour interval, at the dose-levels of 500, 1000 and 2000 mg/kg/day.
From the result described above, it can be concluded that neodymium tris (di-2-ethylhexylphosphate) did not induce any chromosome aberration in-vivo and therefore should not be classified for genetic toxicity.
Short description of key information:
No indication of genetic toxicity was observed in an in vivo micronucleus assay performed with neodymium tris(di-2-ethylhexylphosphate).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the classification criteria of Annex VI Directive 67/548/CEE or UN/EU GHS, and considering the negative result obtained in the in-vivo micronucleus test using neodymium tris (di-2-ethylhexylphosphate), no classification for mutagenicity is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.