5-amino-2-nitrobenzoic acid

Flash point

Administrative data

Endpoint:

flash point of flammable liquids

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the flash point is only relevant to liquids and low melting point solids

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

27 August - 11 September 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

EC No. 440/2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

Batch No.: 10044431
Storage Conditions: Room temperature (approx. 15 to 25 °C)

Key result

Melting / freezing pt.:

249.5 °C

Atm. press.:

1 004.3 hPa

Decomposition:

yes

Decomp. temp.:

ca. 250 °C

During the heating phase a distinct endothermic effect was observed in the temperature range of 240 – 250 °C, which can be assigned to the melting of the test item. The endothermic effect was directly followed by an exothermic effect starting at a temperature of approx. 250 °C with an average decomposition energy of -750 J/g.

No.	Sample weight (mg)	Onset of effect (°C)	Range of effect (°C)	Weight loss (mg)	Atmospheric pressure (hPa)
PN18264	9.44	249.65	240 - 250 (endo) 250 - 320 (exo)	5.04	1004.3
PN18265	10.58	249.26	240 - 250 (endo) 250 - 320 (exo)	4.69	1004.3

As the onset temperatures in both tests deviate by less than 0.5 K from their mean value of 249.46 °C, this temperature can be used as melting point. The test item has a melting point of 249.5 °C accompanied by its decomposition.

Optical verification using the capillary method

To verify the results of the DSC measurement, an additional measurement in a melting capillary was performed in the temperature range of 200 °C to 260 °C with a heating rate of 10 K/min. Starting at a temperature of 240 °C change in colour to a darker tone could be observed. At a temperature of 250 °C the test item was completely molten and turned black. The test was terminated at a maximum temperature of 260 °C. After the measurement a black residue remained in the capillary.

According to the observations during the test in the capillary method, the effects in the DSC measurements with open crucibles can be assigned to the melting of the test item accompanied by its decomposition in the temperature range of 240 °C to 250 °C.

Conclusions:

The test item 5-Amino-2-nitrobenzoic acid (CAS no. 13280-60-9) has a melting point of 249.5 °C at atmospheric pressure (1004.3 hPa) accompanied by its decomposition starting at a temperature of approx. 250 °C as determined by differential scanning calorimetry and capillary method according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).

Executive summary:

The test item 5-Amino-2-nitrobenzoic acid (CAS no. 13280-60-9) has a melting point of 249.5 °C at atmospheric pressure (1004.3 hPa) accompanied by its decomposition starting at a temperature of approx. 250 °C as determined by differential scanning calorimetry and capillary method according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).