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Diss Factsheets
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EC number: 951-985-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimnetal Phase: 14 June 2020 to 05 September 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- ca. 0.004 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 7
- Conclusions:
- The water solubility of the test item has been determined to be 3.96 x 10-3 g/L of solution at 20.0 ± 0.5 °C.
- Executive summary:
Introduction
The water solubility of the test substance was determined using a procedure designed to be compatible with the following guidelines:
- Method A.6 Water Solubility of Commission Regulation (EC) No. 440/2008 of 30 May 2008
- Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995
Method
The determination was carried out using the column elution method using purified water with a resistivity of greater than 15MΩ.
A preliminary test was performed in order to select the appropriate method and to determine the approximate amount of test item to be used in the main test. The column elution apparatus was set up in duplicate (Systems A and B). Each system consisted of a glass micro-column fitted with a plug of glass wool, connected to a recirculating pump and a reservoir holding approximately 500 mL of purified water. Temperature was maintained at 20.0 ± 0.5 °C. An aliquot (0.0527 g) of test item was dissolved in 100 mL of tetrahydrofuran. Glass beads (approximately 1.0 g) were added and the solvent removed using a rotary evaporator (40 °C). The systems were flushed with purified water for approximately 19 hours which was then discarded. The reservoirs were re-filled with fresh purified water and approximately half the coated glass beads loaded into each micro-column. After allowing the coated beads to soak for at least 2 hours, the water in the column was run to waste. Aliquots (approximately 20 mL) of sample solution from each reservoir were taken at intervals of at least ten bed volumes of eluate. The pH of each sample solution was recorded.
The concentration of test item in the sample solutions was determined by high performance liquid chromatography (HPLC).
Results and Conclusion
The water solubility of the test item has been determined to be 3.96 x 10-3g/L of solution at 20.0 ± 0.5 °C.
Reference
Preliminary Test Result
The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was 4.8 x 10-4 g/L. The solution had a pH of 7.0.
Validation of Test System
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0.585 to 4.68 mg/L. The results were satisfactory with a correlation coefficient (r) of 1.000 being obtained.
Description of key information
Water solubility data summary.
Key value for chemical safety assessment
- Water solubility:
- 0.004 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item has been determined to be 3.96 x 10^-3 g/L of solution at 20.0 ± 0.5 °C.
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