Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 808-288-7 | CAS number: 1158363-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 19 to 23 July 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Lot number: 4425-191127
Purity: 99.8% - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all concentrations
- Sampling method: in 0-hour fresh solutions and 48-hour old solutions
- Sample storage conditions before analysis: stored in refrigerator (2-8 °C) - Vehicle:
- yes
- Remarks:
- water
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 0.1001 g test item was weighed and dissolved in 1000 mL of test water by magnetic stirring for about 5 hours. After the test item was dissolved completely, the solution of 100 mg/L was used to dilute other solutions and for exposure. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: Applied Chemistry Department Pesticide Environmental Evaluation Laboratory of China Agricultural University.
- Age of parental stock (mean and range, SD): less than 24 hours old
ACCLIMATION
- Acclimation period:
- Acclimation conditions (same as test or not): same with test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 140 to 250 mg/L (as CaCO3)
- Test temperature:
- 18~22oC
- pH:
- 6.0 to 8.5 pH units
- Dissolved oxygen:
- not less than 3 mg/L during the test period
- Nominal and measured concentrations:
- Nominal concentrations: 10, 18, 32, 56 and 100 mg/L; Measured concentrations: 11.796, 19.022, 34.288, 65.592, 108.968 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL glass beakers
- Volume of solution: 50 mL per vessel
- Aeration: no aeration to vessels
- Renewal rate of test solution (frequency/flow rate): no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The dilution water was tap water after being treated with Aquapro Pure Water System
- Total organic carbon: < 2 mg/L
- Intervals of water quality measurement: 0, 48 h
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hr light: 8 hr dark
- Light intensity:
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Biological observation: Observation intervals: 24 hours and 48 hours after exposure.
Method: Each test vessel was checked for immobilized daphnids. In addition to immobility, any abnormal behavior or appearance were recorded. Those animals that are not able to swim within 15 seconds, after gentle agitation of the test vessel are considered to be immobilized (even if they can still move their antennae).
VEHICLE CONTROL PERFORMED: yes
RANGE-FINDING STUDY
- Test concentrations: 0.1, 1, 10 and 100 mg/L
- Results used to determine the conditions for the definitive study: During the period of 48 hours, no immobilization or any toxic signs were observed in the control group and the test groups of 0.1, 1, 10 mg/L. 100% immobilization occurred in the test group of 100 mg/L after 24 hours. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 28.43 mg/L
- 95% CI:
- 24.88 - 32.5
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Physicochemical Measurements in the Definitive Test:
The determined values of dissolved oxygen were 8.20 ~ 8.58 mg/L, the pH values were between 7.78 ~ 8.20 and the max difference was 0.42. Hardness of test water measured was 160 mg/L (as CaCO3). The temperature was 19.1 ~ 20.0 oC, the difference was 0.9 oC.
Toxic Signs in the Definitive Test:
During the 48-hour exposure period, no immobilization and abnormal behavior or appearance was observed in the control group and the test group of 10 mg/L, the daphnids exposed to 18 and 32 mg/L test groups showed abnormal behavior such as immobilization, 100% inhibition occurred in 56 and 100 mg/L test groups after 48 hours.
Verification of Test Concentration in the Definitive Test:
The concentrations of test item were determined in samples of test media by HPLC method. Analysis of the concentration of the test item were performed in 0 hour fresh solutions and 48 hours old solutions. The results showed that the determined concentrations in 0-hour fresh media were 105.7% ~ 118.0% of nominal concentrations, the determined concentrations in 48 hours old media were 110.9% ~ 118.1% of nominal concentrations. The test concentrations were satisfactorily maintained in the range of 80 - 120% of nominal concentration. - Results with reference substance (positive control):
- EC50-24 h of potassium dichromate to Daphnia magna was 1.54 mg/L, and the 95% confidence limits was 1.34 ~ 1.79 mg/L. The results met the recommended criterion in OECD Guideline No. 202: EC50-24 h of potassium dichromate is within the range of 0.6 mg/L to 2.1 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour EC50 of the test item to Daphnia magna was determined to be 28.43 mg/L.
- Executive summary:
A Daphnia acute immobilization test of the substance was conducted with Daphnia magna over a 48-hour exposure period, according to OECD Guideline 202.
The 48-hour EC50 of the test item to Daphnia magna was determined to be 28.43 mg/L.
Reference
Description of key information
A Daphnia acute immobilization test of the substance was conducted with Daphnia magna over a 48-hour exposure period, according to OECD Guideline 202.
The 48-hour EC50 of the test item to Daphnia magna was determined to be 28.43 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 28.43 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.