(R)-2-(2,4-Difluorphenyl)-1,1-difluor-3-(tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluorethoxy)-phenyl]-2-pyridyl}-2-propanol-(R,R)-tartrate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2020-02-25 to 2020-03-09

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

no

Type of method:

effusion method: Knudsen cell

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Worst case estimation of the vapour pressure at 20 °C

Key result

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Worst case estimation of the vapour pressure at 25 °C

Key result

Test no.:

#3

Temp.:

50 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Worst case estimation of the vapour pressure at 50 °C

The vapour pressure was measured in the temperature range 40 °C to 110 °C. The measured vapour pressures at the corresponding temperatures are shown in Table 1. After the measurement a mass loss of ca. 0.3% (w/w) was determined.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature [°C]	Vapour pressure [hPa]
40	< 1 x 10Exp-5
50	< 1 x 10Exp-5
60	< 1 x 10Exp-5
71	< 1 x 10Exp-5
81	< 1 x 10Exp-5
90	< 1 x 10Exp-5
100	1.00 x 10Exp-5
110	1.34 x 10Exp-5

Vapour pressure at last measurement at 70 °C: 1.05 x 10Exp-5 hPa; Detection limit: 1 x 10Exp-5 hPa

Up to a temperature of 90 °C the measured vapour pressures were below the detection limit of 1 x 10 Exp-5 hPa. Since the test did not yield vapour pressures sufficiently high to extrapolate to 20, 25 and 50 °C these values were estimated according to the Antoine equation. The last data point of the measurement at 110 °C was used as starting point for the calculation. The measured vapour pressure at 110 °C was 1.34 x 10Exp-5 hPa. Calculated vapour pressures are listed in Table 2.

Table 2: Calculated vapour pressures at 20, 25 and 50 °C

T [°C]	p [hPa]	p [Pa]
20	< 1.3 x 10Exp-9	< 1.3 x 10Exp-7
25	< 2.6 x 10Exp-9	< 2.6 x 10Exp-7
50	< 5.1 x 10Exp-8	< 5.1 x 10Exp-6

This is a conservative estimation of the vapour pressure of the test item for the listed temperatures. In order to further ensure a conservative approach the vapour pressures were rounded up to the next order of magnitude in order to obtain final upper limit values for the vapour pressure (Table 3).

Table 3: Final upper limit values of the vapour pressure at 20, 25 and 50 °C

T [°C]	p [hPa]	p [Pa]
20	< 1.0 x 10Exp-8	< 1.0 x 10Exp-6
25	< 1.0 x 10Exp-8	< 1.0 x 10Exp-6
50	< 1.0 x 10Exp-7	< 1.0 x 10Exp-5

Conclusions:

The obtained upper limit vapour pressures for the test item are:
20 °C: < 1.0 x 10Exp-6 Pa
25 °C: < 1.0 x 10Exp-6 Pa
50 °C: < 1.0 x 10Exp-5 Pa

Executive summary:

The vapour pressure of the test item was determined according to OECD guideline 104 by the effusion method. Since the vapour pressure measurement did not yield vapour pressures sufficiently high to extrapolate to 20, 25 and 50 °C, these values were estimated according to the Antoine equation. Based on the highest measured vapour pressure at 110 °C, the following upper limit vapour pressure values for the test item were obtained from calculated vapour pressures:

20 °C: < 1.0 x 10Exp-6 Pa

25 °C: < 1.0 x 10Exp-6 Pa

50 °C: < 1.0 x 10Exp-5 Pa

Description of key information

The vapour pressure of the test item was determined according to OECD guideline 104 by the effusion method. Since the vapour pressure measurement did not yield vapour pressures sufficiently high to extrapolate to 20, 25 and 50 °C, these values were estimated according to the Antoine equation. Based on the highest measured vapour pressure at 110 °C, the following upper limit vapour pressure values for the test item were obtained from calculated vapour pressures:

20 °C: < 1.0 x 10Exp-6 Pa

25 °C: < 1.0 x 10Exp-6 Pa

50 °C: < 1.0 x 10Exp-5 Pa

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C