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Diss Factsheets
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EC number: 852-824-2 | CAS number: 1404220-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report that meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Other (1981). The method employed in the testing, evaluation, and the scoring of the results was adopted from the U.S. Federal Hazardous Substances Act Regulations study guidelines, 16 CFR, section 1500.3. [Comparable to OECD Test Guideline 401].
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Diisodecyl phenyl phosphite
- EC Number:
- 247-098-3
- EC Name:
- Diisodecyl phenyl phosphite
- Cas Number:
- 25550-98-5
- Molecular formula:
- C26H47O3P
- IUPAC Name:
- Phosphorous acid, diisodecyl phenyl ester
- Details on test material:
- - Name of test material (as cited in study report): Diisodecyl phenyl phosphite
- Lot/batch No.: PDDP-002-03240A
- Commercial, purity: Not stated (Phosphorus content = 7.09%)
- Supplier: Borg Warner Company, Parkersburg, WV
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 and 300 grams
- Fasting period before study: Animals were fasted overnight prior to dosing, but were not deprived of water.
- Housing: The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR, Part 3.
- Diet: Following administration the animals were allowed food ad libitum
- Water: Following administration the animals were allowed water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The sample was dosed as supplied (described as a colorless to straw-colored liquid).
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- other: Used for data submission
- Details on study design:
- - Duration of observation period following administration: 21 days
- The animals were observed daily for signs of toxicity and mortality.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 other: g/kg
- Remarks on result:
- other: no deaths
- Mortality:
- No animals died during the experiment
- Clinical signs:
- other: After 1 hour the animals (number not specified) appeared slightly depressed and ruffled. After 24 hours the animals appeared to improve and within 48 hours the animals were essentially normal.
- Gross pathology:
- Gross pathological examination revealed no remarkable findings.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- No deaths occurred at 5 g/kg body weight, the LD0 = 5 g/kg bw, the LD50 > 5 g/kg/
- Executive summary:
No deaths occurred at highest dose of 5 g/kg.
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