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Diss Factsheets
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EC number: 951-589-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles. GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 24 hour exposure, occlusive wrap
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Gasoline
- EC Number:
- 289-220-8
- EC Name:
- Gasoline
- Cas Number:
- 86290-81-5
- Reference substance name:
- unleaded gasoline
- IUPAC Name:
- unleaded gasoline
- Test material form:
- other: low viscosity liquid hydrocarbon
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: non-abraded and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Observations were made and 24 and 72 hours and at 7 and 14 days after treatment.
- Number of animals:
- 6 animals
- Details on study design:
- Observations were not made at 48 hours. Therefore, the mean erythema and mean edema scores do not reflect a 24, 48, and 72 hour average, rather they reflect a 24 and 72 hour average.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- other: 72 hrs
- Score:
- ca. 0.92
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Out of compliance with OECD guidelines: 24 hour exposure, occlusive wrap
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Not Specified
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- other: 24 hrs
- Score:
- ca. 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: Out of compliance with OECD guidelines: 24 hour exposure, occlusive wrap
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- other: 72 hrs
- Score:
- ca. 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: Out of compliance with OECD guidelines: 24 hour exposure, occlusive wrap
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- other: 7 days
- Score:
- ca. 0.92
- Max. score:
- 1
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: Out of compliance with OECD guidelines: 24 hour exposure, occlusive wrap
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 24/72 hr time point average
- Time point:
- other: 24/72 hr
- Score:
- ca. 0.5
- Max. score:
- 0.5
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: Out of compliance with OECD guidelines: 24 hour exposure, occlusive wrap
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Not Specified
- Other effects:
- Unleaded motor gasoline was administered via an occlusive dermal patch on abraded skin. The erythema scores at 24 and 72 hours and at 7 and 14 days were 0.0, 1.0, 0.17, and 0.0, respectively. Erythema was fully reversible within 14 days after treatment. The edema scores at 24 and 72 hours and at 7 and 14 days were 0.5, 0.5, 1.08, and 0.0, respectively. Edema was fully reversible within 14 days after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The results of this study cannot be directly interpreted for classification of skin irritation due to deviations from the EEC regulatory protocol, consisting of the use of a 24 hr, rather than a 4 hr, exposure period and the use of an occlusive, rather than a semi-occlusive, wrap.
- Executive summary:
Unleaded motor gasoline (API PS-6) was administered via occlusive dermal patch on non-abraded and abraded skin of 6 New Zealand White rabbits at doses of 0.5 ml for 24 hours to assess dermal irritation. Clinical observations were made at 24 and 72 hours and at 7 and 14 days after treatment. Unleaded motor gasoline produced dermal irritation (erythema and edema) to the skin of rabbits as a result of 24 -hour exposure. Erythema was fully reversible within 7 days and edema was fully reversible within 14 days.
The erythema and edema scores of unleaded motor gasoline (API PS-6) indicated a potential to cause dermal irritation.
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