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Diss Factsheets
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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- other: Peer-reviewed journal article (published literature)
- Adequacy of study:
- weight of evidence
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Collection of results published in review article
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 302 A (Inherent Biodegradability: Modified SCAS Test)
- Version / remarks:
- Soil and sediment sample tests reported in the study appear to have studied according to a protocol equivalent or similar to OECD 302.
- Deviations:
- not specified
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study authors additionally perform calculations, which agree with the reported soil/sediment studies; references for the methodology are provided in the published journal article, and the journal article has been peer-reviewed.
- GLP compliance:
- not specified
- Inoculum or test system:
- natural soil
- Remarks:
- A selection of field-samples of natural sediments and soils, plus theoretical calculations.
- Details on inoculum:
- The authors report on results from both calculations and sampling of natural sediments and soils, with good consistency between the various result-types.
- Parameter:
- % degradation (O2 consumption)
- Value:
- 50
- Sampling time:
- 30 d
- Remarks on result:
- other: Not readily biodegradable
- Remarks:
- Maximum reported time. Possibly inherently biodegradable; however study only considered primary degradation.
- Details on results:
- Indication is provided that the substance may be inherantly biodegradable, but only primary-degradation is considered, and ready-biodegradability criteria are not met. Author concludes from both field-studies and calculations that the substance is not readily-biodegradable. With an assumed value of 3-30 L/kg of the test item in aerobic soil, the calculated half-life was 3-22d and the values reported in field-studies conducted by methods similar or equivalent to OECD302 ranged from 1-30d.
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Indication is provided that the substance may be inherantly biodegradable, but only primary-degradation is considered, and ready-biodegradability criteria are not met. Author concludes from both field-studies and calculations that the substance is not readily-biodegradable. With an assumed value of 3-30 L/kg of the test item in aerobic soil, the calculated half-life was 3-22d and the values reported in field-studies conducted by methods similar or equivalent to OECD302 ranged from 1-30d.
- Executive summary:
Indication is provided that the substance may be inherantly biodegradable, but only primary-degradation is considered, and ready-biodegradability criteria are not met. Author concludes from both field-studies and calculations that the substance is not readily-biodegradable. With an assumed value of 3-30 L/kg of the test item in aerobic soil, the calculated half-life was 3-22d and the values reported in field-studies conducted by methods similar or equivalent to OECD302 ranged from 1-30d.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6
- Deviations:
- not applicable
- GLP compliance:
- not specified
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Details on results:
- The model predicts the test-item to not be readily biodegradable. The model suggests a modest possibility of primary degradation but not ultimate degradation within the relevant time window.
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The assessment indicates that the prediction is suitable for the regulatory conclusion set out in section 4.1.; although at higher tonnage levels (Annex VIII and above) additional information is recommended to be provided in accordance with the tonnage driven information requirements. This conclusion is with due regard to REACH Article 25(1) and impact on the weight of evidence including new physicochemical, environmental fate and/or newly generated in vitro information. The monoconstituent substance does not meet the criteria of being readily biodegradable.
- Executive summary:
The outcome of the model for all constituents and impurities are considered suitable to support the assessment of the ready biodegradability of the substance. The model indicates that the main constituent of the substance is not readily-biodegradable, and is unlikely to exceed the 60 % pass level set by the OECD Guidelines for testing of Chemicals (301) for ready biodegradability of a substance, which is consistent with other information available in published, peer-reviewed literature. Additionally, this prediction is intended as supporting information in a weight-of-evidence approach for the endpoint, in support of published information that shows the substance to not be readily biodegradable.
Referenceopen allclose all
Indication is provided that the substance may be inherantly biodegradable, but only primary-degradation is considered, and ready-biodegradability criteria are not met. Author concludes from both field-studies and calculations that the substance is not readily-biodegradable. With an assumed value of 3-30 L/kg of the test item in aerobic soil, the calculated half-life was 3-22d and the values reported in field-studies conducted by methods similar or equivalent to OECD302 ranged from 1-30d.
Description of key information
Biodegradation: not readily biodegradable; possibly inherantly biodegradable, primary-degradation half-life 1 -30d, (weight of evidence approach, 2020).
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
Biodegradation: not readily biodegradable; possibly inherantly biodegradable, primary-degradation half-life 1 -30d, (weight of evidence approach, 2020).
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