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EC number: 603-493-6 | CAS number: 131560-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- March 22, 1996
- GLP compliance:
- yes
- Remarks:
- Study director
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- triphenyl[(2E,4E,6E)-3,7,11-trimethyldodeca-2,4,6,10-tetraen-1-yl]-λ⁵-phosphane
- EC Number:
- 603-493-6
- Cas Number:
- 131560-11-7
- Molecular formula:
- C33 H38 P
- IUPAC Name:
- triphenyl[(2E,4E,6E)-3,7,11-trimethyldodeca-2,4,6,10-tetraen-1-yl]-λ⁵-phosphane
- Test material form:
- semi-solid (amorphous): gel
- Details on test material:
- Charge: B 15S
Purity: 78.7 g/100 g (HPLC)
State: highly viscous gel
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Manufacturing date: August 1998
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, exclusion of oxygen (under nitrogen)
- Solubility and stability of the test substance in the solvent: proven good solubility
FORM AS APPLIED IN THE TEST: solution
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- chbb: thorn
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Boehringer Ingelheim Pharma KG
- Age at study initiation: young
- Weight at study initiation: 177-180 g (male), 175-181 g (female)
- Fasting period before study: animals were given no feed at least 16 hours before administration, but water was available ad libitum
- Housing: single in stainless steel wire mesh cages, type DK-III (Becker & Co., Castrop-Rauxel, FRG)
- Diet: Kliba-Labordiaet, Provimi Kliba SA, Kaiseraugst, Switzerland, ad libitum
- Water: tap water ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- bidest
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Doses:
- 200 mg/kg (2 kg/ 100 mL), 2000 mg/kg (20 kg/ 100 mL) only tested in three separate females
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days for the 200 mg/kg dose group; 1 day for the 2000 mg/kg dose group
- Frequency of weighing: shortly before application (day 0), weekly thereafter and at the end of the study (before fasting period)
- Clinical signs including body weight recorded several times on the day of administration
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - <= 2 000 mg/kg bw
- Mortality:
- 2000 mg/kg dose group: all animals died 1 day after application
200 mg/kg dose group: delayed mortality observed in 1 male and 1 female rat, which died 6 and 11 days after application, respectively - Clinical signs:
- other: 2000 mg/kg dose group: impaired general state and dyspnoea 200 mg/kg dose group: impaired and poor general state, dyspnoea, gasping, apathy, staggering, spastic gait, diarrhea, exsiccosis, extended abdomen, red discoloured urine, compulsary gnawing and re
- Gross pathology:
- - dilation of the stomach and of the small and large intestine with gaseous or watery contents and erythema of the small intestine
Any other information on results incl. tables
Table 1: Symptoms of the male animals (cageside observations)
Dose (mg/kg) 200 |
numer animals (n) with symptoms |
time period showing symptoms |
Impaired general state |
3/3 |
h1 d1-d2 |
Poor general state |
3/3 |
d1-d2 |
Dyspnoea |
3/3 |
h1-h4 d5-d9 |
Gasping |
1/3 |
h1-d2 |
Apathy |
3/3 |
h1-h4 |
Staggering |
1/3 |
h1-h4 |
Piloerection |
3/3 |
h1-d9 |
Diarrhea |
1/3 |
h3-h4 |
Exsiccosis |
1/3 |
d5-d9 |
Weight reduction |
1/3 |
d7-d9 |
Extended abdomen |
1/3 |
d9 |
Red clammy snout |
1/3 |
d1 |
h: hour, d: day
Table 2: Symptoms of the female animals (cageside observations)
Dose (mg/kg) |
200 |
2000 |
||
|
numer animals (n) with symptoms |
time period showing symptoms |
numer animals (n) with symptoms |
time period showing symptoms |
Impaired general state |
1/3 |
d6-d9 |
3/3 |
h2-h4 |
Poor general state |
3/3 |
h1-h5 d2-d3 |
|
|
Dyspnoea |
3/3 |
d2-d3 d2-d9 |
3/3 |
h2-h4 |
Apathy |
3/3 |
h1-h5 d2-d3 |
|
|
Staggering |
3/3 |
h5 d2-d3 |
|
|
Spastic gait |
1/3 |
d3 |
|
|
Piloerection |
3/3 |
h5 d2-d9 |
|
|
Smeared fur |
2/3 |
d2-d3 |
|
|
Diarrhea |
3/3 |
h5 |
|
|
Exsiccosis |
2/3 |
d2-d3 |
|
|
Discoloured urine red |
1/3 |
d3 |
|
|
compulsory gnawing |
3/3 |
h1-h2 |
|
|
Red clammy snout |
2/3 |
d2-d3 |
|
|
h: hour, d: day
Table 3: Mortality of the female animais (cumulative)
Dose |
(mg/kg): |
200 |
No.of |
animals: |
3 |
after: |
|
|
h0 |
|
0 |
d11 |
|
1 |
d14 |
|
1 |
Table 4: Mortality of the female animais (cumulative)
Dose |
(mg/kg): |
200 |
2000 |
No.of |
animals: |
3 |
3 |
after: |
|
|
|
d1 |
|
0 |
3 |
d6 |
|
1 |
|
d14 |
|
1 |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the conditions of this study the median lethal dose of the test substance after oral application was found to be greater than 200 mg/kg and less or equal to 2000 mg/kg body weight.
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