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Diss Factsheets
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EC number: 695-938-6 | CAS number: 678966-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2009-05-12 to 2009-06-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Batch No.: 08111121
Purity: 98% - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals: 0, 10 min
- Buffers:
- pH 4.0:
Potassium dihydrogen orthophosphate (3.0 g) and disodium hydrogen orthophosphate dodecahydrate (6.4 g) were dissolved in purified water (950 mL) and the pH was adjusted to 4.0 ± 0.05 with orthophosphoric acid. The volume was then adjusted to 1000 mL with purified water.
pH 7.0:
Potassium dihydrogen orthophosphate (13.6 g) was dissolved in purified water (1900 mL), 1M sodium hydroxide (60 mL) was added and the pH was confirmed to be 7.0 ± 0.05. The volume was then adjusted to 2000 mL with purified water.
pH 9.0:
Disodium tetraborate decahydrate (16.6 g) and potassium dihydrogen orthophosate (1.8 g) were dissolved in purified water (950 mL) and the pH was adjusted to 9.0 ± 0.05 with 1M hydrochloric acid. The volume was then adjusted to 1000 mL with purified water. - Duration:
- 10 min
- pH:
- 4
- Temp.:
- 10 °C
- Duration:
- 10 min
- pH:
- 7
- Temp.:
- 10 °C
- Duration:
- 10 min
- pH:
- 9
- Temp.:
- 10 °C
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- At each of pH 4, 7 and 9 and 10 ± 0.5ºC, greater than 50% hydrolysis had occurred after 10 minutes. At pH 9, the rate of hydrolysis was so rapid that the test substance was not detected at the initial timepoint.
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- No.:
- #3
- No.:
- #4
- Key result
- pH:
- 4
- Temp.:
- 10 °C
- DT50:
- < 10 min
- Key result
- pH:
- 7
- Temp.:
- 10 °C
- DT50:
- < 10 min
- Key result
- pH:
- 9
- Temp.:
- 10 °C
- DT50:
- < 10 min
- Details on results:
- pH of test solutions: The results show that there was a significant decrease in pH (from nominal test pH) in each case, consistent with rapid production of the breakdown product, hydrofluoric acid.
- Conclusions:
- The test substance was determined to be hydrolytically unstable under acidic, neutral and basic conditions, with a half-life of less than 10 minutes at 10ºC.
- Executive summary:
A study was performed to determine the rate of hydrolysis of the test substance as a function of pH in accordance with the preliminary test according to EU Method C.7 and the OECD Guidelines for Testing of Chemicals, Method 111. As method development work had indicated extremely rapid hydrolysis, the procedure was conducted at 10ºC.
The preliminary study showed that at each of pH 4, 7 and 9 and 10 ± 0.5ºC, greater than 50% hydrolysis had occurred after 10 minutes. No further testing was necessary.
The test substance was determined to be hydrolytically unstable under acidic, neutral and basic conditions, with a half-life of less than 10 minutes at 10ºC.
Reference
Description of key information
The test substance was determined to be hydrolytically unstable under acidic, neutral and basic conditions, with a half-life of less than 10 minutes at 10ºC.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 10 min
- at the temperature of:
- 10 °C
Additional information
A study was performed to determine the rate of hydrolysis of the test substance as a function of pH in accordance with the preliminary test according to EU Method C.7 and the OECD Guidelines for Testing of Chemicals, Method 111. As method development work had indicated extremely rapid hydrolysis, the procedure was conducted at 10ºC.
The preliminary study showed that at each of pH 4, 7 and 9 and 10 ± 0.5ºC, greater than 50% hydrolysis had occurred after 10 minutes. No further testing was necessary.
The test substance was determined to be hydrolytically unstable under acidic, neutral and basic conditions, with a half-life of less than 10 minutes at 10ºC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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