4-(cyclohexylamino)butane-1-sulfonic acid

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 April 2019 - 08 May 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Version / remarks:

2016

Deviations:

no

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

Version / remarks:

Rev. 6 (2015)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

Test item is a powder.

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

other: The substance does ignite but does not propagate combustion either by burning with flame or smouldering

The flame of the gas burner did ignite the test item pile.  The test item melted, burned with a orange yellow flame and turned into a black residue. Grey smoke was observed. After removal of the ignition source, the flame extinguished after 3 seconds and no propagation of combustion was observed. 

Interpretation of results:

other: not classified based on GHS or CLP criteria

Conclusions:

The substance is not a flammable solid.

Executive summary:

A GLP study according to EC A.10 and UN Test N.1 was performed. In the preliminary screening test, the substance does ignite but does not propagate combustion either by burning with flame or smouldering along 200 mm of the test item pile within 2 minutes. The substance melted in contact with the flame. The substance is concluded to be not a flammable solid.

Reference 2

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

In a statement based on structural features (see below in quotes) it was concluded that the substance has no pyrophoric properties. Additionally study reports (e.g. for determination of density) do not mention any pyrophoric effect during handling the substance. In accordance with UN RTDG/MTC/Appendix 6/Screening procedures/Section 5.2 for substances which may be liable to spontaneous combustion, no further data are required.

Full statement as presented in the study report:
"A test item is considered pyrophoric when it ignites within five minutes of coming in contact with air. The molecular structure of the test item is shown in Paragraph 4.1. The test item does not contain groups that might lead to ignition in contact with air. Since the purity of the test item is determined at 99.94% (see Appendix 2), the impurities were not taken into account, as no effects from the impurities are expected. In conclusion, 4-(cyclohexylamino)butane-1-sulfonic acid has no pyrophoric properties."

Reason / purpose for cross-reference:

data waiving: supporting information

Reference 3

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 April 2019 - 08 May 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Version / remarks:

Rev. 6 (2015)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

Particle size distribution: D10= 20.3 µm; D50= 74.7 µm; D90=143 µm

Key result

Test procedure:

100 mm sample cube at 140°C

Result:

negative outcome (no effect observed)

After the experiment, the consistency of the sample was unchanged, i.e. no reaction and/or decomposition of the test item was observed.

Interpretation of results:

other: not classified based on GHS or CLP criteria

Conclusions:

The substance is not self-heating.

Executive summary:

In a GLP study according to UN Test N.4, a negative result was obtained using a 10 cm sample cube at 140°C. From this it was concluded that 4-(cyclohexylamino)butane-1-sulfonic acid is not a self-heating substance.

Reference 4

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

Justification for type of information:

Statement as presented in the study report (see below in quotes) was based on the molecular structure of the substance (see Reference substance '4-(cyclohexylamino)butane-1-sulfonic acid').
In the water solubility study (see cross reference) there was no mentioning of any release of flammable gas.
In accordance with UN ST/SG/AC.10/11/Rev.6 (RTDG- Manual of Tests and Criteria) Appendix 6-Screening procedures/Section 5.3 for substances which in contact with water may react to emit flammable gases, no further data are required. The classification procedure for substances which may react with water to emit flammable gases does not need to be applied.

Full statement as presented in the study report:
"A test item is considered highly flammable when it ignites spontaneously in contact with water, or evolves a flammable gas at a minimum rate of ≥ 1 litre/kg of the substance per hour.
The molecular structure of the test item is shown in paragraph 4.1. The test item does not contain groups that might lead to ignition in contact with water and/or to the evolution of a flammable gas. Since the purity of the test item is determined at 99.94% (see Appendix 2), the impurities were not taken into account, as no effects from the impurities are expected.
In conclusion, 4-(cyclohexylamino)butane-1-sulfonic acid is considered ‘not highly flammable’ in contact with water."

Reason / purpose for cross-reference:

data waiving: supporting information

Reason / purpose for cross-reference:

data waiving: supporting information

Description of key information

Not a flammable solid (EC A.10, UN Test N.1: preliminary screening test)

No pyrophoric properties (based on experience in handling and structural features).

Not highly flammable in contact with water (based on experience in handling and structural features).

Not a self-heating substance (UN Test N.4).

Key value for chemical safety assessment

Flammability:

not classified

Justification for classification or non-classification

Classification or non-classification according to CLP Regulation (EC) No. 1272/2008:

Not a flammable solid (negative in UN Test N.1)

Not a pyrophoric solid (the substance lacks functional groups that would imply this hazard)

No classification for the hazard "Substances which in contact with water emits flammable gases' (the substance lacks functional groups that would imply this hazard)

Not a self-heating substance (negative UN Test N.4 at 140°C)