Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 619-409-6 | CAS number: 99208-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The aim of this study is to assess the hazardous potential of the substance 10-(2, 5-Dihydroxyphenyl)-10H-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO-HQ) with respect to repeated dose toxicity and related reproductive and developmental toxicity effects. The assessment will include expert analysis on the reactivity and possible transformations of the target chemical as well as in silico predictions.
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: QSAR prediction
- Principles of method if other than guideline:
- Experimental developmental toxicity data for HQ and a phosphinate (CAS 84434-11-7, ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate), that could be used as analogue to DOPO are available in TB (see Table 4 presented below-"Experimental Developmental toxicity (NOEL/NOAL) data for HQ fragment and another phosphinate which could be considered as analogous to DOPO").
According to the ECHA dossiers [17, 23] the experimental studies for both chemicals are conducted according to OECD TG 414 (Prenatal Developmental Toxicity Study). The study of HQ gave no indication for a potential developmental or reproductive hazard of hydroquinone [23]. Krasavage et. al (1992) also reports that the HQ is not selectively toxic to developing conceptuses and does not appear to be a developmental toxicant [24]. - GLP compliance:
- no
Test material
- Reference substance name:
- 9-(2,5-dihydroxyphenyl)-8-oxa-9λ⁵-phosphatricyclo[8.4.0.0²,⁷]tetradeca-1(14),2,4,6,10,12-hexaen-9-one
- EC Number:
- 619-409-6
- Cas Number:
- 99208-50-1
- Molecular formula:
- C18H13O4P
- IUPAC Name:
- 9-(2,5-dihydroxyphenyl)-8-oxa-9λ⁵-phosphatricyclo[8.4.0.0²,⁷]tetradeca-1(14),2,4,6,10,12-hexaen-9-one
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- other: QSAR predictions on several anaogues
Results and discussion
Results: maternal animals
General toxicity (maternal animals)
- Details on results:
- Experimental developmental toxicity data for HQ and a phosphinate (CAS 84434-11-7, ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate), that could be used as analogue to DOPO are available in TB (see Table 4 as was shown).
According to the ECHA dossiers [17, 23] the experimental studies for both chemicals are conducted according to OECD TG 414 (Prenatal Developmental Toxicity Study). The study of HQ gave no indication for a potential developmental or reproductive hazard of hydroquinone [23]. Krasavage et. al (1992) also reports that the HQ is not selectively toxic to developing conceptuses and does not appear to be a developmental toxicant [24].
The maternal toxicity of the phosphinate (CAS 84434-11-7) was assessed to be 100 mg/kg bd/d [23]. In fetuses, three skeletal variations affecting the skull, ribs and sternebrae were assessed as treatment-related but not as adverse. These minor and reversible effects indicate a developmental delay which is reversible. Thus, the no observed adverse effect level (NOAEL) for prenatal developmental toxicity is 300 mg/kg bw/d while the no observed effect level (NOEL) for prenatal developmental toxicity is 100 mg/kg bw/d.
Both structures (HQ and CAS 84434-11-7) with their experimental data are used to predict the target chemical. NO(A)EL of DOPO-HQ is predicted to be
174 mg/kg bw/d (Figure 9, see attached full report).
Effect levels (maternal animals)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 300 mg/kg bw/day (nominal)
- Based on:
- other:
- Remarks:
- QSAR prediction
- Basis for effect level:
- other: QSAR data
- Remarks on result:
- other:
- Remarks:
- QSAR data
Results (fetuses)
Effect levels (fetuses)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 174 mg/kg bw/day
- Based on:
- other: QSAR data
- Sex:
- not specified
- Basis for effect level:
- other: QSAR data
- Remarks on result:
- other: QSAR data
Fetal abnormalities
- Key result
- Abnormalities:
- effects observed, treatment-related
- Localisation:
- skeletal: skull
- skeletal: rib
- Description (incidence and severity):
- In fetuses, three skeletal variations affecting the skull, ribs and sternebrae were assessed as treatment-related but not as adverse. These minor and reversible effects indicate a developmental delay which is reversible.
Overall developmental toxicity
- Key result
- Developmental effects observed:
- not specified
- Lowest effective dose / conc.:
- 100 mg/kg bw/day
- Treatment related:
- yes
Applicant's summary and conclusion
- Conclusions:
- Conclusions on developmental toxicity:
The NO(A)EL of DOPO-HQ with respect to developmental toxicity is predicted to be 174 mg/kg bw/d.
Based on the phosphinate properties with respect to AChE inhibition and the available experimental data for HQ and DOPO`s analogues (CAS 84434-11-7), it could be assumed that the target chemical (DOPO-HQ) will have no or very low developmental toxicity. - Executive summary:
Experimental developmental toxicity data for HQ and a phosphinate (CAS 84434-11-7,ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate), that could be used as analogue to DOPO are available in TB(seeTable 4below).
Table 4.Experimental Developmental toxicity (NOEL/NOAL) data for HQ fragment and another phosphinate which could be considered as analogous to DOPO
Exp. data
(test organism)
Toolbox database
HQ
NOEL = 25 mg/kg bdwt/d
(rabbit)
ECHA CHEM
NOEL = 75 mg/kg bdwt/d
(rabbit)
ECHA CHEM
NOEL = 100 mg/kg bdwt/d
(rat)
ECHA CHEM
NOEL = 100 mg/kg bdwt/d
(rat)
ECHA CHEM
CAS 84434-11-7
NOEL = 100 mg/kg bdwt/d
ECHA CHEM
NOAEL = 300 mg/kg bdwt/d
ECHA CHEM
According to the ECHA dossiers [17, 23] the experimental studies for both chemicals are conducted according to OECD TG 414 (Prenatal Developmental Toxicity Study). The study of HQ gave no indication for a potential developmental or reproductive hazard of hydroquinone [23].Krasavage et. al (1992) also reports that the HQ is not selectively toxic to developing conceptuses and does not appear to be a developmental toxicant [24].
The maternal toxicity of the phosphinate (CAS 84434-11-7) was assessed to be 100 mg/kg bd/d [23].In fetuses, three skeletal variations affecting the skull, ribs and sternebrae were assessed as treatment-related but not as adverse. These minor and reversible effects indicate a developmental delay which is reversible. Thus, the no observed adverse effect level (NOAEL) for prenatal developmental toxicity is 300 mg/kg bw/d while the no observed effect level (NOEL) for prenatal developmental toxicity is 100 mg/kg bw/d.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.