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EC number: 406-810-4 | CAS number: 40649-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-03-04 to 1990-05-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-propylcyclohexanone
- EC Number:
- 406-810-4
- EC Name:
- 4-propylcyclohexanone
- Cas Number:
- 40649-36-3
- Molecular formula:
- C9H16O
- IUPAC Name:
- 4-propylcyclohexan-1-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Chbb: THOM
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Thomae, Biberach
- Age at study initiation: about 5 to 9 weeks
- Weight at study initiation (mean): 185 (169-207) g
- Fasting period before study: The rats did no receive any food from 17 hours before up to 4 hours after treatment.
- Housing: They were housed under conventional conditions in a 60 m² room with daylight and artificial fluorescent ligth (6 a.m. - 6 p.m.). The treated rats were kept separately in Makrolon cages type III (floor area: 37.5 x 21 cm = 787.5 cm², height: 15 cm) on mobile racks. During the acclimatization phase and on the day of treatment, the animals were kept on metal grids (placed above the softwood granulate) and then on conventional softwood granulate as bedding. The cages and the metal grids had been machine-cleaned before the beginning of the study. The bedding was changed three times a week.
- Diet: ad libitum, Altromin Strandard Diet Total Pathogen Free TPF N1324
- Water: ad libitum, tap water
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24 - 29 °C
- Humidity (%): 33 - 46%
- Photoperiod: light phase from 6 a.m. to 6 p.m.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 3.31 mL/kg
- Doses:
- 1500, 2000, 2500 and 3000 mg/kg
- No. of animals per sex per dose:
- 1500, 2500 and 3000 mg/kg: 5 females;
2000 mg/kg: 5 males and 10 females;
A further 10 animals (5 males and 5 females) from another study (T 13319) served as controls for body weight development. - Control animals:
- yes
- Remarks:
- control rats were treated with 10 mL/kg of 0.25% aqueous Methocel K 4M Premium solution)
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: Behavior and general condition of all rats were monitored for 4 - 6 hours after administration and then checked daily. All rats were weighted before treatment, as well as on days 2, 4, 6, 8, 11, 13 and 15 of the study.
- Necropsy of survivors performed: yes
All the rats which died and which were sacrificed at the end of the study by CO2-asphyxia were subjected to gross pathological investigation. - Statistics:
- The body weight data were processed by means of the program TOX 511 A, developed by the Department of Technical and Scientific Data Processing of E. Merck, Darmstadt.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Only one female rat dosed with 2000 mg/kg died 6 hours after treatment. All the other rats survived the observation period.
- Body weight:
- Inhibition of body weight development and decreased body weight were observed on day 2 mainly.
- Gross pathology:
- In the female rat that died and all the rats that were sacrificed at the end of the observation period no organ alterations were seen.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the result of this study, it is concluded that the test material has no acute toxic potential. The LD50 for males and females, after an observation period of 15 days was >2000 mg/kg.
- Executive summary:
A study according OECD TG 401 was performed to determine the acute toxicity of the test item after oral administration of 1500, 2000, 2500 and 3000 mg/kg bw to rats. The animals were observed for 15 days. Behavior and general condition of all rats were monitored for 4-6 hours after administration and then checked daily. All rats were weighed before treatment, as well as on days 2, 4, 6, 8, 11, 13 and 15 of the study. Necropsy was performed. Intoxication symptoms started directly after treatment and lasted up to day 2. The symptoms were: Dyspnea, locomotor disturbance, lateral and abdominal position, piloerection, salivation, pale faeces, retention of faeces, increased lacrimation, and wet anal region. Only one female rat dosed with 2000 mg/kg died 6 hours after treatment. All the other rats survived the observation period. Inhibition of body weight development and decreased body weight were observed on day 2 mainly. In the female rat that died and all the rats that were sacrificed at the end of the observation period no organ alterations were seen. The median lethal dose (LD50 ) for males and females, after an observation period of 15 days, was > 2000 mg/kg bw.
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