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EC number: 407-130-0 | CAS number: 65232-89-5 BP AMOCO IV; E-326 CATALYST; KAT MSA; MSA-KATALYSATORTABLETTEN
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Irritation:
- skin: not irritating (rabbit)
- eye: risk of serious damage to eyes (rabbit)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05.07.1988 - 29.08.1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Animals Inc., Denver, Pennsylvania.
- Age at study initiation: young adults (at least 8 weeks old)
- Weight at study initiation: no data
- Housing: individually
- Diet: Lab Rabbit Chow HF (Purina #5326), 125 g/day while on test.
- Water: tap water, ad libitum.
- Acclimation period: 55 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 - 21 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12 h / 12 h - Type of coverage:
- semiocclusive
- Preparation of test site:
- other: closely clipped
- Vehicle:
- physiological saline
- Controls:
- other: untreated skin of the same animals served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 x 0.5 grams
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.25 ml - Duration of treatment / exposure:
- 4 h
- Observation period:
- 3 days
- Number of animals:
- 6 (2 males, 4 females).
- Details on study design:
- TEST SITE
- Type of wrap if used: gauze and porous tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess test material was removed using dry gauze.
- Time after start of exposure: 4 h
SCORING SYSTEM: draize score - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h - 48 - 72 h
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Reference
Erythema findings: right front/left front:
Time | animal 1 | animal 2 | animal 3 | animal 4 | animal 5 | animal 6 |
0,5 h | 1/0 | 0/1 | 0/0 | 0/1 | 0/0 | 0/0 |
24 h | 0/1 | 0/0 | 0/0 | 0/1 | 0/0 | 0/0 |
48 h | 1/1 | 0/0 | 0/0 | 0/1 | 0/0 | 0/0 |
72 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Edema findings: right front/left front:
Time | animal 1 | animal 2 | animal 3 | animal 4 | animal 5 | animal 6 |
0,5 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
24 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
48 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
72 h | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
The test substance produced only mild to transient dermal irritation. The only irritation seen was slight (barely perceptible) erythema in three of the six animals, which subsided within one to three days.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30.08.1988 - 27.09.1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hazleton-Dutchland Inc., Denver, Pennsylvania.
- Age at study initiation: young adults (at least 8 weeks old)
- Weight at study initiation: no data
- Housing: individually
- Diet: Lab Rabbit Chow HF (Purina #5326), 125 g/day while on test.
- Water: tap water, ad libitum.
- Acclimation period: 56 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 - 21 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12 h / 12 h - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the adjacent eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 cm3 - Duration of treatment / exposure:
- Single application, eyes were not washed after treatment.
- Observation period (in vivo):
- 28 days
- Number of animals or in vitro replicates:
- 6 (3 males and 3 females)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No wash was performed after application of the material. Approximately 24 h after application, the treated eyes were rinsed to remove any residual test application.
SCORING SYSTEM: draize score
TOOL USED TO ASSESS SCORE: fluorescein - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 28 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 1.1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 28 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 2.7
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 28 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 2.4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 28 days
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification: risk of serious damage to eyes
Reference
Findings animals 1/2/3/4/5/6 (undiluted test substance):
Time | Opacity | Iritis | Conjunctival Erythema | Conjunctival Chemosis | ||||||||||
1 h | +/+/+/0/+/+ | +/0/+/+/0/+ | 2/1/1/1/1/1 | 0/0/0/0/0/1 | ||||||||||
24 h | 2/1/2/2/2/2 | 1/1/1/1/1/1 | 3/3/3/3/3/3 | 3/3/3/3/3/3 | ||||||||||
48 h | 2/+/2/1/2/2 |
2/1/1/1/1/1 | 3/3/3/2/2/3 | 3/2/3/2/2/2 | ||||||||||
72 h | 2/+/1/+/+/+ | 2/1/1/1/+/1 | 3/2/3/2/2/2 | 2/2/2/2/2/2 | ||||||||||
7 d | 2/+/1/2/+/1 | 2/1/1/1/0/+ | 2/2/2/2/1/2 | 1/1/2/1/1/1 | ||||||||||
14 d | 2/+/2/1/0/0 | 2/1/1/0/0/0 | 2/2/1/2/2/1 | 2/1/1/1/0/0 | ||||||||||
28 d | 2/+/2/2/0/0 | 0/0/0/0/0/0 | 1/1/1/1/0/0 | 1/0/0/1/0/0 |
The test substance caused serious damage to eyes. All six animals exhibited severe conjunctival irritation (redness, chemosis, discharge, necrosis), corneal opacity, ulceration and iridial damage. All six animals also exhibited pannus (neovascularization of the corneal surface) one or more times between days 7 and 28. On day 7 one animal had an enlarged blood vessel on the anterior surface of the iris. Two animals had a fluid filled blister on the corneal surface on day 21 and/or 28. Three animals were noted to have hair loss around the eye. All six animals continued to exhibit severe irritation at termination of the study (day 28).
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
In the key study (BIO/DYNAMICS, 1998; Validity 2) performed according to EPA-guideline OPP 81-5 (Acute Dermal Irritation) and GLP, the potential of the test article to cause acute dermal irritation or corrosion was assessed by a topical application of 2x 0.5 g of the test substance to two test sites on the intact skin of 6 white New Zealand rabbits for 4 hours under semi-occlusive dressing. The only irritation seen was slight (barely perceptible) erythema in three of the six animals, which subsided within one to three days. The average score (24 to 72 hours) for irritation was calculated to be 0.1 for erythema and 0.0 for edema.
Eye irritation:
In the key study (BIO/DYNAMICS, 1998; Validity 2) performed according to EPA-guideline OPP 81-4 (Acute Eye Irritation) and GLP, the potential of the test article to cause damage to the eye was assessed in 6 white New Zealand rabbits, subjected to a single occular application of 1cm³ volume of the test substance. All six animals exhibited severe conjunctival irritation (redness, chemosis, discharge, necrosis), corneal opacity, ulceration and iridial damage. All six animals also exhibited pannus (neovascularization of the corneal surface) one or more times between days 7 and 28. On day 7 one animal had an enlarged blood vessel on the anterior surface of the iris. Two animals had a fluid filled blister on the corneal surface on day 21 and/or 28. The effects were not reversible within the 28-day observation period.
Respiratory Irritation:
There are several epidemiological studies linking upper respiratory symptoms to vanadium pentoxide exposure (Kiviluoto, 1980; Kiviluoto et al., 1979a; Lewis, 1959, Zenz and Berg, 1967 Zenz et al. 1962). Effects were observed even after single exposure (e.g. Zenz & Berg, 1967). Long-term chronic exposure data of workers in the vanadium industry are reported in several publications by Kiviluoto et al. In a factory manufacturing vanadium pentaoxide, 63 workers exposed toV2O5 at concentrations of 0.1 to 3.9 mg V/m3 measured as total dust for 11 years (average 0.2-0.5 mg V/m3) did not have an increased prevalence of upper respiratory symptoms in the case study by Kiviluoto et al (1979a,b, 1980, 1981a,b). However, other epidemiological data support that respiratory symptoms are observed at exposure concentrations of V2O5 that are above 0.1 mg/ V/m3.
According to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, Annex VI, V2O5 is classified with STOT SE 3.
Justification for classification or non-classification
Based on the available data on the registered substance and as well as the pentavalent vanadium compound Divanadium pentoxide (CAS 1314-62-1) and according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 Divanadyl pyrophosphate (CAS 65232-89-5) has to be classified as Eye Damage 1 (H318) and STOT SE 3 (H335). No classification for skin irritation is warrented.
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