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EC number: 602-997-3 | CAS number: 124495-18-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- TSN 100010
XDE-795
Purity: 98.7% - Analytical monitoring:
- yes
- Details on sampling:
- Analytical standards were prepared in solutions of dimethylformamide/ daphnid dilution water (20%/80%) at concentrations encompassing the nominal concentration range of the test solutions and were analyzed with each set of samples to calibrate the detector response. Test solutions were sampled, centrifuged for 30 minutes at 4000 rpm, and analyzed on each day of the study (days 0, 1, and 2). On days 0 and 2 each individual replicate test beaker was sampled and analyzed. On day 1 composite samples were prepared from both the 24-h old (day 0) test solutions and from the renewal test solutions and analyzed. Samples were analyzed by high performance liquid chromatography with ultraviolet detection (HPLC/UV). Since samples were centrifuged, the soluble fraction of the total XDE-795 was selectively determined in these analyses. The amount of XDE-795 was calculated using the average peak response from duplicate injections of each test sample and the response factor ratio of the appropriate standard.
- Vehicle:
- yes
- Remarks:
- acetone
- Details on test solutions:
- Test vessels were 250 mL borosilicate glass beakers containing 200 mL of test solution or dilution water, and were covered with watch glasses to reduce evaporation. Each test vessel was labeled with a unique number for identification purposes.
In the definitive test 30 instars (three replicates; 10 instars/replicate) were exposed to each toxicant concentration and controls. As the test material is immiscible in water, a carrier solvent, acetone, was used to prepare an initial stock solution. The test concentrations did not exceed the maximum limit of 0.5 ml acetone/L or 0.1 mL acetone/200mL. A carrier solvent control was also set. Based on the range-finding test results the nominal concentrations set in the definitive test were 0.0161, 0.0321, 0.0642, 0.128, 0.257, 0.513, and 1.030 mg/L. Test solutions were renewed and daphnids transfered to the new solutions after 24 hours exposure. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Source: laboratory stock
- Age: <24 hours
- Test type:
- other: static renewal at 24 hours
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 168mg/L
- Test temperature:
- 20 ±1°C
- pH:
- 7.6
- Dissolved oxygen:
- 8.0-8.6 (> 90% saturation)
- Conductivity:
- 460 umhos / cm
- Nominal and measured concentrations:
- Nominal: 0.016,0.032,0.064,0.128,0.257, 0.513 and 1.030 mg/L and acetone and daphnid dilution water controls
Measured: 0.014,0.030,0.060,0.118,0.228, 0.312 and 0.228 mg/L and acetone and daphnid dilution water controls - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL borosilicate beakers
- Test volume: 200 mL
- No. of organisms per vessel: 30 (3 replicates/treatment;10 organisms/replicate)
OTHER TEST CONDITIONS
- Photoperiod:16-h light/B-h dark - Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.08 mg/L
- Nominal / measured:
- meas. (not specified)
- Basis for effect:
- mortality
- Details on results:
- The acute (48 hour) LC50 for daphnids was 0.09 mg/L. Sublethal effects were noted at dose levels greater than or equal to 0.06 mg/L and the no observed effect concentration was 0.030 mg/L. Dose-related mortality was observed from 0.060 through the highest dose tested. The dose-response relationship was erratic between the 0.228, 0.118 and 0.060 mg/L analyzed concentration levels with high to intermediate mortality (30/30 and 18/30) observed in the 0.228 and 0.060 mg/L dose groups, respectively, and low mortality (4/30) observed in the 0.118 mg/L dose group. This anomaly cannot be readily explained.
- Validity criteria fulfilled:
- yes
- Conclusions:
- 48-hr EC50 (daphnia magna) = 0.08 mg/L
- Executive summary:
The test substance was tested for its acute toxicity to the cladoceran, Daphnia magna Straus. The objective was to provide an estimate of the 48-hour toxicity of XDE-795 fungicide. The nominal dose levels used to set the test were 0.016, 0.032, 0.064, 0.128, 0.257, 0.513, and 1.030 mg/L. These levels corresponded to analyzed chemical concentrations of 0.014,0.030,0.060,0.118,0.228,0.312, and 0.228 mg/L. The nominal dose levels of 0.128, 0.257, 0.513 and 1.030 mg/L exceeded the reported aqueous solubility of XDE-795 (0.116 mg/L at ambient room temperature). An acetone and daphnid dilution water control were also included in the study. The study was conducted according to OECD guideline 202 and EC Method C.2
In order to statistically evaluate the data and estimate the 24 and 48 hour EC50 and LC50 values, the results from the 1.030 mg/L nominal concentration were excluded from the analysis since the soluble concentration (0.228 mg/L) was less than that of the next lower concentration (0.312 mg/L). The 24-h LC50 was 0.28 mg/L and the 24-h EC50 was 0.13 mg/L. The 48- h LC50 was 0.09 mg/L and the 48-h EC50 was 0.08 mg/L. Lethal effects and sublethal effects (immobility) were evident from 0.060 mg/L through the highest dose tested (analyzed concentration). Therefore, the lowest-Iethal-effect-concentration (LLEC) and the lowest adverse effect concentration (LAEC) were 0.060 mg/L. The no observed effect concentration (NOEC) was 0.030 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-3 (Estuarine/Marine Fish, Mollusk, or Shrimp Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Quinoxyfen (XDE-795) Technical
TSN 100097
Purity: 97.4% - Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- Dimethyl formamide (DMF)
- Test organisms (species):
- Americamysis bahia (previous name: Mysidopsis bahia)
- Test type:
- flow-through
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 22.1 – 22.5 °C
- pH:
- 7.8 - 8.0
- Dissolved oxygen:
- 6.4 - 7.7 mh/L
- Salinity:
- 11-17 ppt
- Nominal and measured concentrations:
- Nominal: 0 (control and solvent control), 13, 22, 36, 60, and 100 µg/L.
Measured: NO (none detected at or above the limit of quantitation of 0.298 µg/L; control and solvent control), 11.6, 19.9, 31.8, 51.2, and 90.0 µg/L. - Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 79.2 µg/L
- Nominal / measured:
- meas. (not specified)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 31.8 µg/L
- Nominal / measured:
- meas. (not specified)
- Validity criteria fulfilled:
- yes
- Conclusions:
- 96-hr LC50 (mysid) = 79.2 µg/L
96-hr NOEC (mysid) = 31.8 µg/L - Executive summary:
The acute toxicity of the test substance to the mysid, Americamysis bahia, was conducted according to EPA OPP 7203. The test was performed under flow-through conditions with five concentrations of test substance, a dilution water control, and a solvent control (0.10 mL/L dimethylformamide) at a mean temperature of 22.4 °C. The dilution water was natural seawater collected at T.R. Wilbury Laboratories in Marblehead, Massachusetts, and adjusted to a salinity of 11 to 17 parts per thousand (ppt) with deionized water. Juvenile mysids used in the test were obtained from an in-house culture. They were less than 24 hours old and in good condition at the beginning of the study. Nominal concentrations of were 0 µg/L (control and solvent control), 13, 22, 36, 60, and 100 µg/L. Mean measured concentrations were ND (none detected at or above the limit of quantitation of 0.298 µg/L; control and solvent control), 11.6, 19.9, 31.8, 51.2, and 90.0 µg/L.
Exposure of the mysid, Americamysis bahia, to the test substance resulted in a 96-hour median lethal concentration (LC50) of 79.2 µg/L, with a 95% confidence interval of 59.7 to >90.0 µg/L. The 96-hour no-observed effect concentration (NOEC) was 31.8 µg/L.
Referenceopen allclose all
Ninety-five to one hundred percent survival occurred in the control and solvent control, and no sublethal effects were noted in the controls during the exposure period. Mysids exhibiting lethargy and/or erratic swimming were observed in test vessels with mean measured concentrations of 51.2 µg/L at 24, 48, and 96 hours, and 90.0 µg/L at 24, 48, 72, and 96 hours. At the conclusion of the test the control mysids had an average wet weight of 0.22 mg (loading rate was 0.00015 g/L at any time and 0.000022 g/L 24 hours).
Description of key information
48-hour EC50 (Daphnia magna): 0.08 mg/L; OECD 202; Reliability = 1
96-hour EC50 (Americamysis bahia): 79.2 µg/L; EPA OPP 72-3; Reliability = 1
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.08 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 79.2 µg/L
Additional information
Acute aquatic invertebrate tests were conducted in one freshwater species and one marine species. The 48-h EC50 value in Daphnia magna is 0.08 mg/L. Marine species tested Americamysis bahia observed a 96-h EC50 value of 79.2 µg/L. The most sensitive acute 48h EC50 for freshwater aquatic invertebrates is less than 1 mg/L.
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