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Diss Factsheets
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EC number: 606-711-8 | CAS number: 211385-45-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- December 21st, 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Version / remarks:
- adopted April 4th, 1984
- Deviations:
- yes
- Remarks:
- see details on test conditions
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- solid
- Specific details on test material used for the study:
- Purity: 95.6 % [w/w]
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Dispersion treatment: 10 min. ultrasonic treatment at room temperature
Stock solution: 100 mg/L, directly weighing for test concentrations 100 - 10000 mg/L
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Non adapted activated sludge.
Source: Municipal sewage treatment plant, D-31137 Hildesheim
The sludge was washed twice with autoclaved tap water and diluted 1:3.
Nutrient solution: Synthetic waste water according to OECD 209
Dry sludge concentration: 3.2 g/L
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 18 - 22°C
- Nominal and measured concentrations:
- Nominal: 0.1, 1.0, 10, 100, 1000 and 10000 mg/L
- Details on test conditions:
- Deviations to the test guideleine:
- In contrats to the guideline, it was decided to use copper(II)sulphate pentahydrate instead of the prescribed 3,5-dichlorophenol.
- In contrast to the guideline the activated sludge was washed only twice, and not three times as described in the guideline.
- A dry sludge concentration of 3 g/L +/- 20% instead of 4 g/L +/- 10% was regarded sufficient for the activated sludge of Hildesheim. - Reference substance (positive control):
- yes
- Remarks:
- Copper(II)sulphate pentahydrate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- 2.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 35 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Confidence interval p = 95% [mg/L]
- Remarks:
- 22 - 54
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- 522 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Reported statistics and error estimates:
- Probit analysis
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item Tetrakis(piperidino)phosphonium chloride is not toxic in concentrations ≤ 2.3 mg/L to activated sludge of a municipal sewage treatment plant.
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