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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: the techniques specified in the Federal Insecticide, Fungicide, and Rodenticide Act (40 CFR 163).
- GLP compliance:
- no
- Remarks:
- GLP not mandatory at this date
Test material
- Reference substance name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
- Molecular formula:
- C32H16N8Co(SO3)n with n=0 to 3
- IUPAC Name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- nine New Zealand White rabbits
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1 g powder.
- Duration of treatment / exposure:
- The treated eyes of six rabbits were left unrinsed. The treated eyes of three rabbits were rinsed after 30 seconds, for 60 seconds with 200 ml of lukewarm tap water.
- Observation period (in vivo):
- Examinations for gross signs of eye irritation were made at 24h, 44h20 or 45h20, and 71h30 and 4, 7, 10 and 13 days following application.
- Number of animals or in vitro replicates:
- 9
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- Without water rinse
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.17
- Max. score:
- 1.7
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Remarks:
- Without water rinse
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.94
- Max. score:
- 1.3
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Remarks:
- Without water rinse
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.22
- Max. score:
- 2.33
- Reversibility:
- not specified
- Irritation parameter:
- chemosis score
- Remarks:
- Without water rinse
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.56
- Max. score:
- 4
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Non-Rinsed Eyes - Irritative effects noted during the study included mild to extreme corneal opacity with from one-quarter or less up to the entire corneal area involved in all rabbits tested. Mild to severe iritis was observed in all animals, as were conjunctival effects including mild to severe erythema and discharge, and mild to extreme edema. Corneal opacity persisted in three animals through most of the observation period and sporadically after day 4 in the remaining animals. Severe vascularization developed in one animal and small cyst-like growths developed in three others.. Conjunctival effects lasted throughout the observation period in most rabbits. The total irritation scores of this group ranged from 2-90.
Rinsed Eyes - No corneal irritation was observed in the rinsed eye group except slight opacity in one rabbit at 48 hours after dosing. This rabbit also had minor iritis at the 24-hour reading. Conjunctival effects included very slight to severe erythema and very slight edema. Total
irritation scores ranged from 0-9 in this group throughout the observation period.
Many changes persisted for thirteen days after application.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Under tests conditions, many changes persisted for thirteen days after application. Therefore, test material is classified as Serious eye damage, Cat 1.
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