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Diss Factsheets
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EC number: 201-145-4 | CAS number: 78-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-OECD guideline study and Non GLP study. Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Two animals treated simultenaously
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutylamine
- EC Number:
- 201-145-4
- EC Name:
- Isobutylamine
- Cas Number:
- 78-81-9
- Molecular formula:
- C4H11N
- IUPAC Name:
- 2-methylpropan-1-amine
- Details on test material:
- - Name of test material (as cited in study report): isobutylamine
- Physical state: clear liquid
- Analytical purity: not stated
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG
- Age at study initiation: not stated
- Weight at study initiation: 1.5 to 2.0 kg
- Housing: singly
- Diet: standard diet ERKA 8300 ad libitum
- Water: tap water ad libitum
- Acclimation period: not applicable
ENVIRONMENTAL CONDITIONS
no details reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
- Duration of treatment / exposure:
- 1 hour
- Observation period:
- 1 hour
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: two areas, each 2.5 cm x 2.5 cm.
- Skin: intact and scarified
- Type of wrap if used: cotton gauze, covered by a PVC film, held in place by an elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: not stated
- removal of test patch: 1 hour after start of exposure
EVALUATION
- Time after start of exposure: 1 hour
SCORING SYSTEM: not defined
Results and discussion
In vivo
Results
- Irritation parameter:
- other: not evalutated due to obvious corrosion
- Basis:
- other: see above
- Time point:
- other: 1 hour post application
- Reversibility:
- not reversible
- Remarks on result:
- other: Deep skin corrosion; evalution of irritation parameters not needed
- Irritant / corrosive response data:
- Inspection of the intact skin test site after the 1-hour expsoure period revealed superficial chaps and colorless exsudation; pigmentation (green-brown-black) of the corroded skin; deep skin corrosion.
,, dark red erythema and deep skin corrosion was noted. - Other effects:
- Animals were excited 20 min past application and inactive thereafter.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Remarks:
- Migrated information R 34 Criteria used for interpretation of results: other: EU, 67/548 EEC; Annex VI
- Conclusions:
- Isobutylamine caused full thickness corrosion of the the rabbit's skin within a 1-hour exposure period.
- Executive summary:
Isobutylamine caused full thickness corrosion of the rabbit's skin within a 1-hour exposure period in a valid non-GLP study conducted similar to OECD TG 404 (two Albino Himalayan rabbits tested; 0.5 mL undiluted test substance applied to intact skin) (Hoechst, 1979).
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