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EC number: 442-390-9 | CAS number: 40573-09-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 11, 2007 - January 11, 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP with acceptable restriction
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- MV 31
- IUPAC Name:
- MV 31
- Details on test material:
- - Name of test material (as cited in study report): MV 31
- Substance type: pure active substance
- Physical state: Colorless, clear liquid
- Analytical purity: 98.97%
- Expiration date of the lot/batch: 31 December 2007
- Storage condition of test material: Refrigerator, 2 -8°C, dark, under inert gas, closed
Constituent 1
Study design
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT:
- Apparatus: HPLC System Agilent 1100 series; HPLC pump G1312 A, Autosampler G1313A:column oven G1316A, degaser G1322A.
- Type, material and dimension of analytical (guard) column: stationary phase: LiChrospher 100 CN 5 µm by Duratec (18304-04); material: stainless steel; dimension: 250 mm x 4.6 mm; Column temperature: 25°C;
- Detection system: UV/VIS detector G1315B by agilent. Detection wavelength at 210 nm (dead time marker and calibration substances), 200 nm (test item);
MOBILE PHASES:
- Type: acetonitrile/distilled water 65:35 (v/v), isocratic elution;
- Experiments with additives carried out on separate columns: no
- pH: Not known
- Solutes for dissolving test and reference substances: dead time marker and calibration substances were dissolved in acetonitrile and diluted in the mobile phase; test substance was dissolved and diluted in the mobile phase.
DETERMINATION OF DEAD TIME:
- Method: by inert substances which are not retained by the column: 22.7 µg of formamide was dissolved in acetonitrile and diluted 0.1 to 1 in the mobile phase and injected twice. The mean dead time of the test system was 3.07 minutes.
REFERENCE SUBSTANCES
- Identity: Acetanilide; Atrazine; Monuron; Triadimenol; Linuron; Pyrazophos; Diclofop-methyl. It is notable that the reference substances are aromatic compounds and/or pesticides. The reference substances are approved for use in the method, but bear little or no structural similarity to the test substance. This is a limitation of the test guideline.
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 3.97 µg
- Quantity of reference substances: 0.84 - 1.59 µg
- Intervals of calibration: None
REPETITIONS
- Number of determinations: Two (duplicate) injections
EVALUATION
- Calculation of capacity factors k': k' = (Tr - T0) / T0, where: Tr = retention time;
T0 = mean column dead time (formamide peak);
- Calculation of retention times: mean retention times were taken for the unretained and test substance retention times only. Retention times for the duplicated injections of the reference substance peaks were used to generate the regression curve.
- Determination of the log Koc value: Linear regression according to calibration curve of the log k of the reference substances as function of log Koc
log Koc = a +b x logk
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- 3.7
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: 3.59 - 4.72 min (See table 1)
- Details of fitted regression line (log k' vs. log Koc):
1st measurement: a = 5.75, b = 6.10, r² = 0.9479, log Koc = 3.68
2nd measurement: a = 5.75, b = 6.12, , r² = 0.9483, log Koc = 3.69
- Graph of regression line attached: See Figure 1.
- Average retention data for test substance: 4.48 min.
- Average log Koc for test substance: 3.68
Any other information on results incl. tables
Table 1. Koc determination of MV 31
Substance |
Tr,1 [min] |
Tr,2 [min] |
mean Tr (n=2) |
K |
Log K |
log Koc |
Formamide (t0) |
3.07 |
3.07 |
3.07 |
|
|
|
|
|
|
|
|
|
|
Measurement 1 |
|
|
||||
Acetanilide |
3.59 |
|
0.17 |
-0.77 |
1.25 |
|
Atrazine |
3.83 |
|
0.25 |
-0.60 |
1.81 |
|
Monuron |
3.79 |
|
0.24 |
-0.63 |
1.99 |
|
Triadimenol |
3.91 |
|
0.27 |
-0.56 |
2.40 |
|
Linuron |
4.15 |
|
0.35 |
-0.45 |
2.49 |
|
Pyrazophos |
4.32 |
|
0.41 |
-0.39 |
3.65 |
|
Diclofop-methyl |
4.71 |
|
0.54 |
-0.27 |
4.20 |
|
|
Log Koc = 5.75 +6.10 log K (r² = 0.9479) |
|||||
MV 31 |
4.47 |
0.46 |
-0.34 |
3.68 |
||
|
|
|||||
Measurement 2 |
|
|
||||
Acetanilide |
3.59 |
|
0.17 |
-0.76 |
1.25 |
|
Atrazine |
3.83 |
|
0.25 |
-0.60 |
1.81 |
|
Monuron |
3.79 |
|
0.24 |
-0.62 |
1.99 |
|
Triadimenol |
3.91 |
|
0.28 |
-0.56 |
2.40 |
|
Linuron |
4.15 |
|
0.35 |
-0.45 |
2.49 |
|
Pyrazophos |
4.33 |
|
0.41 |
-0.39 |
3.65 |
|
Diclofop-methyl |
4.72 |
|
0.54 |
-0.27 |
4.20 |
|
|
Log Koc = 5.75 +6.12 log K (r² = 0.9483)
|
|||||
MV 31 |
|
4.48 |
|
0.46 |
-0.34 |
3.69 |
Applicant's summary and conclusion
- Conclusions:
- Log Koc value of test substance was 3.7.
- Executive summary:
Log Koc value of MV 31 was assessed according to OECD Guideline TG121 "Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using HPLC". Under the analytical conditions used, the test substance had a log Koc value of 3.7.
The study was conducted according to internationally accepted test guidelines and under GLP compliance. The reference substances are approved for use in the method, but bear little or no structural similarity to the test substance. Therefore, this study is considered as reliable with restrictions.
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