Terephthalaldehyde

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187 “Particle Size Analysis by Laser Diffraction”, Handbook K, 2007

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

Terephthalaldehyde

EC Number:

210-784-8

EC Name:

Terephthalaldehyde

Cas Number:

623-27-8

Molecular formula:

C8H6O2

IUPAC Name:

benzene-1,4-dicarbaldehyde

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

Batch (Lot) Number: 180401
Expiry date: 01 April 2020 (retest date)
Physical Description: Light yellow powder
Purity/Composition: 99.6%
Storage Conditions: At room temperature

Results and discussion

Mass median aerodynamic diameter:

ca. 57.2 µm

Geometric standard deviation:

ca. 2.348

Particle size

Particle size 1

Percentile:

D10

Mean:

ca. 14.6 µm

St. dev.:

0.036

Particle size 2

Percentile:

D50

Mean:

ca. 49.1 µm

St. dev.:

0.377

Particle size 3

Percentile:

D90

Mean:

ca. 129 µm

St. dev.:

0.753

Any other information on results incl. tables

During the method development phase of the analysis trials were conducted using the dry

powder module (DPM) only. The results of these trials indicated that the most appropriate

test and material parameters to obtain the optimum measurements were:

Module   : DPM

Dispersant   : Air

Dispersion pressure    : 0.5 barg

Refractive index (sample) : 1.500 n

Absorption   : 0.000 AU

Analysis Model  : General Purpose

Using the identified parameters, the particle size was analysed over the range 0.01 µm to

3500 µm. The results of the formal analysis are presented in Table 9:1. In addition, a graph

of volume (%) versus Particle Diameter (µm), and full particle size distribution, is provided in

Graph 9.A (Average of 5 runs).

Table 9:1 : Full Test Results

	run 1	run 2	run 3	run 4	run 5	average	STDVP	%STDVP
VWM	62.6	62.4	63.0	62.8	62.8	62.7	N/A	N/A
MODE	55.0	54.9	56.0	56.1	56.0	55.6	N/A	N/A
D10	14.6	14.7	14.7	14.6	14.7	14.6	0.0364	0.248
D50 (MEDIAN)	48.7	48.7	49.3	49.3	49.4	49.1	0.377	0.767
D90	128	128	129	129	129	129	0.753	0.585
MMAD	56.7	56.8	57.5	57.5	57.6	57.2	0.393	0.7
GSD	2.350	2.345	2.351	2.348	2.345	2.348	0.002	0.1

All particle size results are in µm

5.27 % by volume of sample was seen to be < 10.00 µm

Definitions

VWM  : volume weighted mean

d10  : 10 % of the test item is less than this particle size

d50  :  50 % of the test item is less than this particle size

d90  :  90 % of the test item is less than this particle size

GSD   : geometric standard deviation of the lognormal particle size distribution

MMAD  : mass median aerodynamic diameter

Average : calculated from the entirety of the data captured in each run and not a

  simple arithmetic mean

STDVP : standard deviation of the population

% STDVP : percentage standard deviation of the population

The coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus

repeatability of the characteristic particles in the size distribution is within the acceptable

limits as per the ISO 13320-1 test standard.

Applicant's summary and conclusion

Conclusions:

The MMAD of the tested sample was measured as 57.2 µm, with a volume weighted mean of 62.7 µm. The particle distribution was as follows: d10 14.6µm, d50 49.1µm and d90 129µm. The volume of sample<10µm was 5.27%.