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EC number: 426-650-9 | CAS number: 191743-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-02-03 - 1998-04-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted on 24th February 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 426-650-9
- EC Name:
- -
- Cas Number:
- 191743-75-6
- Molecular formula:
- Unspecified
- IUPAC Name:
- 2-Aminoethanol reaction products with cyclohexane and peroxidized N-butyl-2,2,6,6-tetramethyl-4-piperidinamine-2,4,6-trichloro-1,3,5-triazine reaction products
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals, Boyertown, PA (on 12/02/97 and 1/20/98)
- Age at study initiation: Animals were born the weeks of 9/30 through 12/11/97, Experimental Start Date: 02/05/98
- Weight at study initiation: 286-300 g (males), 236 - 288 g (females)
- Housing: 5 animals/sex/cage in suspended wire cage, bedding was changed three times/week
- Diet: Fresh Purina Rat Chow, ad libitum, except for 16-20 hours prior to dosing
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: temperature-controlled animal room
- Photoperiod: 12 hours dark / 12 hours light
- Animal room was kept clean and vermin free
IN-LIFE DATES: From: 1998-02-05 To: 1998-02-19
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE:
- Concentration in vehicle: see dosage preparation
- Amount of vehicle (if gavage): no data
- Justification for choice of vehicle: to make dosing by gavage possible
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED:
A single dose was administered orally by syringe and dosing needle at a dose level of 5000 mg/kg bw. All animals received the same concentration of dosing solution.
DOSAGE PREPARATION:
15 g of test item was mixed with corn oil to a total volume of 30 mL - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 2 and 4 hours postdose and once daily for 14 days for toxicity and pharmacological effects
- Animals were observed twice daily for mortality
- Body weights were recorded immediately pretest, on days 3 and 7, at death or at termination in the survivors
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Nine of ten animals survived the 5000 mg/kg bw oral dose.
- Clinical signs:
- Red staining of the nose/mouth area was noted in the animal which died on day 1. Physical signs noted in the survivors included emaciation, chromorhinorrhea, diarrhea and red staining of the nose/mouth area.
- Body weight:
- Body weight changes of male survivors were normal. Weight loss, associated with an obstructed water sipper, was noted in females but all returned to normal by day 14.
- Gross pathology:
- Necropsy results of the animal which died on day 1 revealed that the death was due to a dosing error which resulted in the test item being deposited into the lungs rather than to a toxic effect of the test item. Necropsy results of the survivors were normal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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