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EC number: 412-260-6 | CAS number: 52658-19-2 MONO 442
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 01, 1993 to December 15, 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Olac Ltd. Bicester, Oxon, England
- Strain: Hsd/Ola: Sprague-Dawley (CD)
- Age at study initiation: 4 - 7 weeks
- Weight at study initiation: 100 - 117 g
- Fasting period before study: overnight prior to and 4 hours after dosing
- Housing: in groups of up to 5 rats of the same sex in metal cages with wire mesh floors
- Diet (e.g. ad libitum): standard laboratory diet ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22
- Humidity (%): 50
- Air changes (per hr): 10 - 15
- Photoperiod (hrs dark / hrs light): 12 /12 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DOSAGE PREPARATION (if unusual): not applicable
- Doses:
- 2.0 g/ kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality was checked at least twice daily. Clinical signs were recorded daily. Body weight recorded on day 1 (prior to dosing), 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic examinations - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths following a single oral dose of the test substance at 2.0 g/kg b.w.
- Clinical signs:
- other: Piloerection and increased salivation were observed in all rats within five minutes of dosing. Piloerection persisted until day 2 and was accompanied at later intervals on day 1 by abnormal body carriage (hunched posture) and soft or liquid faeces. Recove
- Gross pathology:
- No macroscopic abnormalities were observed for animals killed on day 15.
- Interpretation of results:
- not classified
- Remarks:
- M
- Conclusions:
- Under the study conditions, the acute lethal oral dose to rats of the test substance was found to be greater than 2000 mg/kg bw/d.
- Executive summary:
A study was conducted to determine the acute oral toxicity of the test substance to rat according to EU Method B.1. A group of ten fasted rats (five males and five females) was administered a single dose of the test substance, as supplied, at a dose level of 2000 mg/kg bw by gavage. All animals were killed and examined macroscopically on Day 15, the end of the observation period. There was no mortality. Clinical signs of reaction to treatment included piloerection, abnormal body carriage (hunched posture), soft or liquid faeces and increased salivation in all rats. Recovery as judged by external appearance and behaviour, was complete by Day 3. No abnormalities were recorded at the macroscopic examination on Day 15. Under the study conditions, the acute oral LD50 of the test substance was found to be greater than 2000 mg/kg bw in rats (Parcell, 1993).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data provided by ECHA on request of Cytec Surface Specialties NV/SA. SNIF last update on 1993-10-25, UUID: SNIF-9afcc480-fb63-3500-a144-c5b56bbd2ec7.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- Annex V
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Hoe: WISKf (SPF 71)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not stated
- Age at study initiation: not stated
- Weight at study initiation: not stated
- Fasting period before study: not stated
- Housing: not stated
- Diet (e.g. ad libitum): not stated
- Water (e.g. ad libitum): not stated
- Acclimation period: not stated
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not stated
- Humidity (%): not stated
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): not stated - Type of coverage:
- occlusive
- Vehicle:
- other: sezam oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: not stated
- % coverage: not stated
- Type of wrap if used: not stated
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not stated
- Time after start of exposure: not stated
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg b.w.
- Concentration (if solution): not stated
- Constant volume or concentration used: not stated
- For solids, paste formed: not stated
VEHICLE
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
- Lot/batch no. (if required): not stated
- Purity: not stated
TEST SITE
- Area of exposure: not stated
- % coverage: not stated
- Type of wrap if used: not stated
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not stated
- Time after start of exposure: not stated
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
VEHICLE
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
- Lot/batch no. (if required): not stated
- Purity: not stated - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Statistics:
- No data
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 2000 mg/kg b.w. Number of animals: 5; number of deaths: 0
Female: 2000 mg/kg b.w. Number of animals: 5; number of deaths: 0 - Clinical signs:
- other: No signs of toxicity related to dose levels. No signs of systemic toxicity were observed.
- Gross pathology:
- Effects on organs:
No macroscopic abnormalities were observed. - Other findings:
- Signs of toxicity (local):
Slight of well defined erythema was observed in all animals from day 2 onwards. This was accompanied in most by scaling, encrustations, indurations of a dry, rough surface. By day 7 on the males and day 13 in the females all skin sites were normal. - Interpretation of results:
- not classified
- Conclusions:
- Under the study conditions, the single dose acute dermal LD50 of the test substance is greater than 2000 mg/kg bw/d in male and female rats.
- Executive summary:
A study was conducted to determine the acute dermal toxicity of the test substance to rat according to EU Method B.3. A single dose of the test substance at 2000 mg kg/bw was applied to the skin of ten healthy rats for 24 h. The animals were observed for mortality, body weights, signs of gross toxicity, and behavioral changes for 14 d. Slight to well-defined erythema was observed in all animals from Day 2 onwards. This was accompanied in most by scaling, encrustations, indurations of a dry, rough surface. By Day 7 in the males and Day 13 in the females, all skin sites were normal. Under the study conditions, the acute dermal LD50 of the test substance was greater than 2000 mg/kg bw in rats (Anonymous, 1993).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute toxicity, oral:
A study was conducted to determine the acute oral toxicity of the test substance to rat according to EU Method B.1. A group of ten fasted rats (five males and five females) was administered a single dose of the test substance, as supplied, at a dose level of 2000 mg/kg bw by gavage. All animals were killed and examined macroscopically on Day 15, the end of the observation period. There was no mortality. Clinical signs of reaction to treatment included piloerection, abnormal body carriage (hunched posture), soft or liquid faeces and increased salivation in all rats. Recovery as judged by external appearance and behaviour, was complete by Day 3. No abnormalities were recorded at the macroscopic examination on Day 15. Under the study conditions, the acute oral LD50 of the test substance was found to be greater than 2000 mg/kg bw in rats (Parcell, 1993).
Acute toxicity, dermal:
A study was conducted to determine the acute dermal toxicity of the test substance to rat according to EU Method B.3. A single dose of the test substance at 2000 mg kg/bw was applied to the skin of ten healthy rats for 24 h. The animals were observed for mortality, body weights, signs of gross toxicity and behavioral changes for 14 d. Slight to well-defined erythema was observed in all animals from Day 2 onwards. This was accompanied in most by scaling, encrustations, indurations of a dry, rough surface. By Day 7 in the males and Day 13 in the females, all skin sites were normal. Under the study conditions, the acute dermal LD50 of the test substance was greater than 2000 mg/kg bw in rats (Anonymous, 1993).
Justification for classification or non-classification
Based on the results of the acute oral and dermal toxicity studies, the substance does not warrant classification for acute toxicity according to EU CLP (1272/2008/EC) criteria.
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