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EC number: 812-958-4 | CAS number: 1078712-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- used as read across
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
- Inoculum or test system:
- activated sludge, non-adapted
- Duration of test (contact time):
- 44 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 47.9
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 61.1
- Sampling time:
- 44 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable, fulfilling specific criteria
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 May to 06 July 2016
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other:
- Justification for type of information:
- This study was conducted in a Chinese laboratory under GLP. However, this study was not directly monitored and, therefore, additional information is provided on an analog substance to confirm that it is readily biodegradable.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 25 mg/L
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- EST CONDITIONS
- Composition of medium: filtered sewage pre-conditioned by aerating secondary effluent for 7 days
- Test temperature: 22 +/- 2 °C
- pH: not stated
- Continuous darkness: yes
SAMPLING
- Sampling frequency: day 1, 3, 6, 8, 11, 14, 16, 18, 21, 24, and 28 - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 64.9
- Sampling time:
- 29 d
- Details on results:
- The test substance met the 10-day window and had the following cumulative degradation at days 1, 3, 6, 8, 11, 14, 16, 18, 21, 24, 28, and 29 days: 0.5, 1.7, 2.0, 4.8, 10.2, 22.0, 37.9, 50.5, 62.3, 64.4, 64.4, 64.9.
- Results with reference substance:
- Degradation of the reference substance was 87.9% after 14 days meeting validitation requirements.
Degradation of the toxicity control was 39.7% after 14 days meeting validation requirements. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- This substance is readily biodegradable as it degraded 64.9% after 28 days and met the 10-day window.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Used an emulsifier to solubilize test material. Read across
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- GLP compliance:
- no
- Inoculum or test system:
- activated sludge, domestic, adapted
- Duration of test (contact time):
- 6 wk
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 86
- Sampling time:
- 14 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
Referenceopen allclose all
Positive control (sodium benzoate) degraded 84% within 6 days.
Description of key information
The notified substance was readily biodegradable in the key study as it reached 64.9% degradation after 28 days, including meeting the 10-day window. This study was conducted in a Chinese laboratory under GLP. However, this study was not directly monitored and, therefore, two supporting studies are provided on an analog substance, CAS 61788-63-4, to confirm that the material is readily biodegradable.
CAS 61788-63-4 was readily biodegradable in a well conducted OECD 301D study (Balk, 1987). This study is Klimisch coded as 2 as it used an emulsifier due to the low water solubility of the test material. A second study with CAS 61788-63-4 (OECD 301B, Battelle, 1992) resulted in rapid but not readily biodegradation. The US EPA screening-level hazard characterization on fatty nitrogen derived amines (September, 2010) typically found these materials to be readily biodegradable with low (P1) persistence; this includes the application of the OECD 301D (Balk, 1987) study to the category as it was deemed of acceptable quality.
CAS 61788-63-4 has a larger molecular weight due to one alkyl chain being longer (C14-18 instead of 2-ethylhexyl). In the case of biodegradation, read across from a larger molecular weight analog with longer alkyl chain lengths is appropriate as the smaller molecular weight analog will degrade more rapidly. Therefore, the weight of evidence supports the application of the key study to conclude that this material is readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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