Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-506-0 | CAS number: 822-89-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-10-10 to 1994-10- 17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
- Study type:
- direct photolysis
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Food and Drug Administration (FDA) Environmental Assessment Technical Assistance Handbook, Section 3.10
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hydroxyl-2-pyridone
- EC Number:
- 212-506-0
- EC Name:
- Hydroxyl-2-pyridone
- Cas Number:
- 822-89-9
- Molecular formula:
- C5H5NO2
- IUPAC Name:
- 1-hydroxy-1,2-dihydropyridin-2-one
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study reports): Oxy PYRION
- Physical state: solid (powder)
- Appearance: white speckled gold powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch n°: 93100020
- Analytical purity: > 96.0%
- Expiration date of the lot/batch: not reported
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: ambient
- Stability under test conditions: not reported
Study design
- Radiolabelling:
- no
- Analytical method:
- high-performance liquid chromatography
- Details on sampling:
- - Sampling method for processing the light exposed and dark control samples: An aliquots (1.0 mL) of sample was removed and transferred to a sub-sample vial and an aliquot (50 µL) of 0.869 M copper (II) nitrate: 0.989 M citric acid (1:1 by vol) was added.
- Sampling intervals/times for pH measurements: 0 hr, 1 hr, 6 hr, 1 day, 2 days, 5 days
- Sampling points for photodegradation: 0 hr, 1 hr, 6 hr, 1 day, 2 days, 5 days - Buffers:
- - pH: 7
- Type and final molarity of buffer: 0.01 M potassium phosphate
The buffer solutions were autoclaved (121°C for 20 minutes) twice after preparation. The pH of the buffer solution was adjusted following autoclaving, where necessary, so that a pH value of exactly 7 was obtained. - Light source:
- Xenon lamp
- Light spectrum: wavelength in nm:
- >= 290 - <= 800
- Relative light intensity:
- ca. 425
- Details on light source:
- - Emission wavelength spectrum: 290 to 800 nm
- Filters used and their purpose: UV special glass filter
- Relative light intensity based on intensity of sunlight: 425W/m2
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test apparatus/vessels: the photolysis cells were 50 mL capacity glass containers, with an outer glass jacket for circulating water and a quartz screw cap lid. Photolysis cells and associated glassware were autoclaved (121 °Cfor 20 min) before use.
- Sterilisation method: the buffer solutions and associated glassware were sterilised using a Denley BA 852 Sovereign Portable Autoclave (Denley Instruments Ltd, Billinghurst, Sussex)
- If no traps were used, type of test system: [closed/open] closed
- Indication of test material adsorbing to the walls of test apparatus: [yes: /no] no
TEST MEDIUM
- Kind and purity of water: All chemicals and reagents were of analytical grade or HPLC grade supplied by Fisons, Loughborough, Leics, or BDH chemicals, Poole, Dorset
REPLICATION
- No. of replicates (dark): 2
- No. of replicates (irradiated): 2
Duration of test at given test condition
- Duration:
- 120 h
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.753 mg/L
- Reference substance:
- no
- Dark controls:
- yes
Results and discussion
Spectrum of substance
- Parameter:
- max lambda
- Value:
- 311 nm
- Remarks:
- molar absorption coefficient of 12441 (log = 4.09)
% Degradationopen allclose all
- % Degr.:
- 57
- Sampling time:
- 1 h
- Remarks on result:
- other: light exposed samples
- % Degr.:
- 100
- Sampling time:
- 6 h
- Remarks on result:
- other: light exposed samples
Dissipation half-life of parent compound
- Key result
- DT50:
- ca. 1 h
- Remarks on result:
- other: due to the rate of photodegradation of oxypyrion, insufficient data was collected to allow determination of the photolysis rate constant (Kp) and half life (T1/2)
- Transformation products:
- not measured
- Details on results:
- In the light exposed samples the concentration of the test substance was 0.43 mg/mL at 1 hour and there was no measurable level of the test substance at 6 hours. There were also no measurable levels of the test substance in samples taken at 1, 2 and 5 days.
The test substance was rapidly photodegraded with a half-life of approximately 1 hour. However, due to insufficient data the photolysis rate constant (Kp) and the half life (t1/2) were not determined.
The test substance was shown to be hydrolytically stable at pH7 (samples incubated in the dark at 25°C).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Nominal test solution conc. for Oxypyrion was 0.5 mg/L, achieved fortification of Oxypyrion in test solutions was 0.9 mg/L. The reason for the achieved fortification being 0.9 mg/L was unknown. However it was considered to affect the validity of the study
- Conclusions:
- A FDA assessment (Section 3.10) has been carried out to obtain preliminary information on the photolysis of Oxypyrion at a single pH in aqueous solution at 25°C. The test substance was rapidly photodegraded with a half-life of approximately 1 hour and no Oxypyrion measurable after 6 hours. However, due to insufficient data the photolysis rate constant and half life were not determined.
The test substance was shown to be hydrolytically stable at pH 7. The results of the study can be considered reliable without restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.